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  • Mike Badolato created a new topic ' Multiple Chemical Sensitivity Etiology Index' in the forum.

    Links in the forums did not carry over in the transfer from the MCS Etiology website to here on EiR. For the convenience of linked studies the forums can be visited on the Etiology website - most...
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  • Mike Badolato created a new topic ' MCS A1 Etiology: Dantoft 2014' in the forum.

    MCS 2 The Etiology of MCS
    MCS 3 Definition and Concensus Criteria
    MCS 3a Criteria Amendment Q and A
    MCS A-1 Etiology: References

    MCS A-1 Etiology : Dantoft 2014

    It is hoped the following will make...

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  • Mike Badolato created a new topic ' MCS A1 Etiology: References' in the forum.

    MCS A-1 Etiology: Dantoft 2014

    References

    Agopyan N et al. Negatively charged 2 and 10 micron particles activate vanilloid receptors, increase cAMP, and induce cytokine release. Tox and Appl Pharm...

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  • Mike Badolato created a new topic ' MCS aa Etiology: Not Always Visible' in the forum.

    The airway epithelium and its sensory innervation become altered to a proinflammatory condition

    Deering-Rice 2011, Hazari 2011, Li 2011, Taylor-Clark 2010, Baulig 2009, 2003a, Calderon-Garciduenas...

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  • Mike Badolato created a new topic ' MCS ab Particulate Vector' in the forum.

    Clean Diesel: Public Health Nightmare

    GERDE P. ET AL. THE RAPID ALVEOLAR ABSORPTION OF DIESEL SOOT-ADSORBED BENZO[a]PYRENE: BIOAVAILABILITY, METABOLISM, AND DOSIMETRY OF AN INHALED PARTICLE-BORNE...

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  • Mike Badolato created a new topic ' MCS ac Etiology: Redox and CYPs' in the forum.

    MCS usually originates from the airway epithelium and its sensory innervation - which has defects due to genetic disposition and environmental exposure.

    A defective airway releases excessive...

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  • Mike Badolato created a new topic ' MCS ac Etiology: Lipid Peroxidation' in the forum.

    A principle feature of oxidative stress is lipid peroxidation - of concern is possible atherogenicity. In the context of complexity - a treatment focused on certain factors could bring a subjective...
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  • Mike Badolato created a new topic ' MCS ad Etiology: Naturally Sensitive' in the forum.

    MCS people are naturally sensitive - in a descriptive portrait attitude and functional typology - genetically introverted intuitive; counterweight to the rarified air of intuition - an extraordinary...
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  • Mike Badolato created a new topic ' MCS ae Etiology: Airway Reactivity' in the forum.

    TRPA1 and TRPV1 may go in hand.

    NASSENSTEIN C. ET AL. EXPRESSION AND FUNCTION OF THE ION CHANNEL TRPA1 IN VAGAL AFFERENT NERVES INNERVATING MOUSE LUNGS J PHYSIOL 586;6:1595-604 2008:

    "...Both TRPA1...

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  • Mike Badolato created a new topic ' MCS af Etiology: Central Sensitization' in the forum.

    Structural and functional alteration of the airway epithelium and its sensory innervation result in central sensitization.

    Rebecca Bascom. Environmental and Airway Diseases Research Facility,...

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  • Mike Badolato created a new topic ' MCS ag Etiology: A Straight Line' in the forum.

    TRPA1: Nassini 2011, Deering-Rice 2011, Taylor-Clark 2010, Caceres 2009, Bessac 2008

    The Etiology of MCS has been presented formally and documented on the website - here is an informal synopsis....

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  • Mike Badolato created a new topic ' MCS ai Etiology: Highlights' in the forum.

    MCS ab Particulate Vector

    GERDE 2001:

    During combustion particles are generated and PAHs (polycyclic aromatic hydrocarbons) form in the gas phase. When the exhaust cools - PAHs adsorb or condense on...

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  • Mike Badolato created a new topic ' MCS aj Etiology: Impossibly Good' in the forum.

    Impossibly Good

    A slower paced, reduced consumption, non combustion lifestyle is needed or human beings will go extinct due to loss of environment and resources.

    Mgt 101 Consume Less or Extinction...

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  • Mike Badolato created a new topic ' MCS ak Etiology: Words to the Wise' in the forum.

    It seems no one wants to believe combustion byproducts are the biggest culprit - reviews of MCS have often been misleading or incomplete - leaving out decades of clear, consistent evidence.

    The...

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  • Mike Badolato created a new topic ' MCS 1 Etiology Narrative' in the forum.

    The etiology includes work at EPA reported by Veronesi 1999-2003 and Roy 2000. Veronesi 2001 may be a most insightful article - yet it seems no one concerned with MCS has referred to it.

    They found...

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  • Mike Badolato created a new topic ' MCS 2 The Etiology of MCS' in the forum.

    MCS A-1 Etiology: Dantoft 2014
    MCS A-1 Etiology: References
    MCS 3 Definition and Concensus Criteria
    MCS 3a Criteria Amendment Q and A
    Credibility:
    MCS 2a Etiology: Notes on References

    The Etiology of...

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  • Mike Badolato created a new topic ' MCS 2a Etiology: Notes on References' in the forum.

    References are of research authorities - conclusions reached in extensive reviews. All statements are fact - documented with the most credible evidence - concise, advanced, and comprehensive....
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  • Mike Badolato created a new topic ' MCS 3 Definition and Concensus Criteria' in the forum.

    MCS A-1 Etiology: Dantoft 2014
    MCS A-1 Etiology: References
    MCS 2 The Etiology of MCS
    Credibility:
    MCS 2a Etiology: Notes on References
    MCS 3a Criteria Amendment Q and A

    The following includes:

    2014...

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  • Mike Badolato created a new topic ' MCS 3a Criteria Amendment Q and A' in the forum.

    MCS 3 Definition and Concensus Criteria
    MCS 2 The Etiology of MCS
    MCS A-1 Etiology: Dantoft 2014

    MCS aj Impossibly Good
    Mgt 101 Consume Less or Extinction
    Mgt 101a Impossibly Good City Design...

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  • Mike Badolato created a new topic ' MCS 4 Top Studies in a Nutshell' in the forum.

    MCS is usually very high levels of neurogenic inflammation - including release of inflammatory cytokines, chemokines, and growth factors

    Mohankumar 2008 - "...release of inflammatory cytokines and...

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  • Mike Badolato created a new topic ' MCS 5 Research Letter' in the forum.

    The research quoted is that of Bascom, Meggs, Veronesi, and Bonham. The three former (Bascom, Meggs, Veronesi) have formed a cornerstone pointing to airway epithelial defects as the cause of most MCS....
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  • Mike Badolato created a new topic ' MCS 6 Neurogenic Inflammation: Delayed Effects' in the forum.

    If overlapping exposures are eliminated so the effect of each can be recognized - it becomes clear that there is often a 36 to 48 hour peak in symptoms after the exposure.

    Guinea pigs reached a peak...

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  • Mike Badolato created a new topic ' MCS 7 Kimata 2004: Neurogenic Inflammation Meas...' in the forum.

    MCS 7 Kimata 2004: Neurogenic Inflammation Measured

    Quotations in the forum MCS 5 Research Paper described the airway epithelial damage found in MCS patients. MEGGS W.J. HYPOTHESIS FOR INDUCTION AND...

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  • Mike Badolato created a new topic ' MCS 8 Airway Origin: Reactive, Measurable and...' in the forum.

    MCS 8 Airway Origin: Reactive, Measurable, and Releasing Systemically

    When MCS people were exposed to capsaicin - cough occurred 5 times (5 coughs) at a concentration .150 far less than both the...

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