By Carol Sieverling

Source : http://www.virtualhometown.com/dfwcfids/medical/nmh.html
DFW CFS and FM Support group : http://www.virtualhometown.com/dfwcfids/

This issue's articles are based on tapes of Carol's October 2000 visit. Dr. Cheney gave permission to share this information, but has not reviewed or edited it.

A year ago Dr. Cheney was prescribing oxygen (with a partial rebreather mask) to increase oxygen transport from the blood into the cells. The benefits were many, but most people found it expensive and difficult to arrange. Dr. Cheney also discovered that the treatment had one flaw: it didn't address the underlying problem of low 2,3 DPG.

2,3 DPG triggers the release of oxygen from the hemoglobin and allows it to enter our tissues. Without enough 2,3 DPG the oxygen cannot release from the hemoglobin into the cells. This oxygen deprivation causes the body to switch over to anaerobic metabolism, which produces tissue acidosis, which is painful. If 2,3 DPG levels can be increased, then more oxygen is transported from the blood into the tissues.

What are the benefits of increased oxygen? They include more energy at the cellular level, suppression of yeast and other pathogens, and prevention of the swelling of the brain due to decreased oxygen.

Dr. Cheney says this swelling of the brain is somewhat common and is the connection between Chiari I and CFIDS. He stated, "Chiari I is a compression phenomenon due to lack of sufficient space at the base of the skull, while CFIDS is a compression phenomenon due to anoxic cerebral edema." (Brain swelling due to lack of oxygen.)

Dr. Cheney asked, "Do you know why Kenyans always win the Boston marathon? They live and train at a high altitude. They run like fiends at 12,000 feet. To compensate for the lack of oxygen at higher altitudes, their bodies make a physiological adjustment—raising 2,3 DPG levels so more oxygen is released. Then the Kenyans go to Boston, which is at sea level, and run their race. However, their bodies are still set for high altitude, so they end up with more oxygen transported into their tissues than other runners. They are super-oxygenated."

Dr. Cheney's goal is to trick our bodies into thinking that we live at a higher altitude, thus raising our 2,3 DPG levels, thereby transporting more oxygen. How? By Dr. Andrew Weil's favorite breathing technique—regulated breath holding.

1. Inhale through your nose for four seconds
2. Hold your breath for seven seconds
3. Exhale through tightly pursed lips, creating "back pressure," for eight seconds.
4. Do this eight times, twice a day, everyday.

That's all it takes to make your body think it lives in Denver instead of Dallas. You must do this regularly for it to work, and it takes weeks for the body to adjust the 2,3 DPG levels. But your oxygen transport will get better and better over time. This method is 3,000 years old, and has 30 years of clinical experience behind it. Dr. Weil believes it is the most powerful way to treat chronic illness. Compared to the rebreather, this is easier, cheaper, more effective, and you cannot overcorrect and get too much O2.

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written by hattan, August 01, 2008

Thanks for posting.

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written by Patrick, December 12, 2008

Out of curiosity, does Cheney have any *blood-based* data showing *deficiencies* of 2,3-DPG? I ask because the only published blood-based study (that I'm aware of) shows *elevations* of 2,3-DPG in CFS (as well as in MCS and FM). A 1998 double blinded study of MCS, FM, and CFS found that patients in all three groups had elevations, and this study went on to win 2nd prize at the Intel International Science and Engineering Fair in 1999. 2,3-DPG helps red blood cells (RBCs) deliver oxygen to tissues that need it the most. Abberations at either end of the spectrum (i.e. both deficiencies *and* elevations) imply that tissues are not adequately oxygenated.

See Dilnaz, P. The pathophysiological basis of Chronic Fatigue Syndrome, Fibromyalgia and Multiple Chemical Sensitivity. Proceedings of the 8th Central European Neuropsychopharmacological Symposium: Psychiatria Danubina, Volume 10, Number 3, pages 340-341, 1998.

- Pat Casanova

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written by Maff, December 12, 2008

Hi Pat,

The truth is I am not sure. It may be that Cheney's theory is based on clinical observations of improvement using his and Dr. Weil's methods and inference from other data. What we do know is well established is that people with ME/CFS, FMS and MCS don't use oxygen efficiently so cells end up being oxygen deprived but there is also an increase in reactive oxygen species/free radicals. Glutathione (GSH) is also universally low in these conditions and in another article Cheney links this to low 2,3-DPG but I don't know what biochemical mechanism he is referring to here. Perhaps the increased oxidative stress due to low GSH contributes to the poor oxygen utilization and supposed low 2,3-DPG. I am just thinking out loud here so your guess is as good as mine.

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written by Patrick, December 12, 2008

Thanks for the reply Maff

long time no chat!

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written by Patrick, December 14, 2008

P.S. Here is another published study showing 2,3-DPG *elevations*

http://64.233.169.132/search?q=cache:YbfbEcEu0q8J:www.cfids-cab.org/rc/Richards-2.pdf+2,3-dpg+CFS&hl=en&ct=clnk&cd=3&gl=us

- Pat

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written by Maff, December 15, 2008

It seems we may have another case of contradictory data.....something which is frustratingly common with ME/CFS and environmental illness.

I do know that Dr. Cheney has noted mild blood alkalosis in most of his chronic fatigue syndrome patients which he attributes to a compensatory mechanism for tissue acidosis (caused by oxygen deprivation/anaerobic respiration). He has said that when treated with oxygen or the breathing thechnique above the blood alkalosis disappears....suggesting improved oxygen delivery to cells and more normal aerobic/anaerobic respiration ratio.

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written by Pat, January 26, 2009

hi Maff, where did my response go?

- Pat

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written by Maff, January 26, 2009

Hi Pat,

Apologies for the loss of your previous comment. The site had to be moved to a new web hosting system as it had outgrown the previous system - unfortunately there were some minor database losses in the process!

This will not happen again and the site should now run faster and more reliably.

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written by tammy, June 17, 2009

creating "back pressure," for eight seconds what this?

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written by Maff, June 17, 2009

Hi Tammy, it means you create a pressure in the air that is directed back into your lungs. It has nothing to do with your back

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