How Vaccinations Work Print E-mail

 

PHILIP F. INCAO, M.D.
1624 Gilpin Street
Denver, CO 80218-1633

 

 

 

In order to use vaccinations wisely, we need to understand exactly how they work. Until recently, the "mechanism of action" of vaccinations was always understood to be simply that they cause an increase in antibody levels (titers) against a specific disease antigen (bacterium or virus), thus preventing "infection" with that bacterial or viral antigen.

 

In recent years science has learned that the human immune system is much more complicated than we thought. It is composed of two functional branches or compartments which may work together in a mutually cooperative way or in a mutually antagonistic way depending on the health of the individual.

 

One branch is the humoral immune system (or Th2 function) which primarily produces antibodies in the blood circulation as a sensing or recognizing function of the immune system to the presence of foreign antigens in the body. The other branch is the cellular or cell-mediated immune system (or Th1 function) which primarily destroys, digests and expels foreign antigens out of the body through the activity of its cells found in the thymus, tonsils, adenoids, spleen, lymph nodes and lymph system throughout the body. This process of destroying, digesting and discharging foreign antigens from the body is known as "the acute inflammatory response" and is often accompanied by the classic signs of inflammation: fever, pain, malaise and discharge of mucus, pus, skin rash or diarrhea.

 

These two functional branches of the immune system may be compared to the two functions in eating: tasting and recognizing the food on the one hand, and digesting the food and eliminating the food waste on the other hand. In the same way, the humoral or Th2 branch of the immune system "tastes" and recognizes and even remembers foreign antigens and the cellular or Th1 branch of the immune system digests and eliminates the foreign antigens from the body. But just as too much repeated tasting of food will ruin the appetite, so also too much repeated stimulation of the "tasting" humoral immune system by an antigen will inhibit and suppress the digesting and eliminating function of the cellular immune system. In other words, overstimulating antibody production can suppress the acute inflammatory response of the cellular immune system! 1

 

This explains the polar opposite relationship between acute discharging inflammations on the one hand and allergies and auto-immune inflammations on the other hand. The more a person has of one, the less he or she will have of the other!

 

A growing number of scientists believe that the increase in America, Europe, Australia and Japan in allergic and auto-immune diseases (which stimulate the humoral or Th2 branch of the immune system) is caused by the lack of stimulation of the cellular or the Th1 branch of the immune system from the lack of acute inflammatory responses and discharges in childhood. 2 3 4 5 We need to identify the factors which cause this shift in the function of the immune system or which cause allergies and auto-immune diseases in childhood to increase!

 

If we now return to the original question of the mechanism of action of vaccinations, we find what I believe is the key to the puzzle. A vaccination consists of introducing a disease agent or disease antigen into an individual’s body without causing the disease. If the disease agent provoked the whole immune system into action it would cause all the symptoms of the disease! The symptoms of a disease are primarily the symptoms (fever, pain, malaise, loss of function) of the acute inflammatory response to the disease.

 

So the trick of a vaccination is to stimulate the immune system just enough so that it makes antibodies and "remembers" the disease antigen but not so much that it provokes an acute inflammatory response by the cellular immune system and makes us sick with the disease we’re trying to prevent! Thus a vaccination works by stimulating very much the antibody production (Th2) and by stimulating very little or not at all the digesting and discharging function of the cellular immune system (Th1).

 

Vaccine antigens are designed to be "unprovocative" or "indigestible" for the cellular immune system (Th1) and highly stimulating for the antibody-mediated humoral immune system (Th2).

 

Perhaps it is not difficult to see then why the repeated use of vaccinations would tend to shift the functional balance of the immune system toward the antibody-producing side (Th2) and away from the acute inflammatory discharging side (the cell-mediated side or Th1). This has been confirmed by observation especially in the case of Gulf War Illness: most vaccinations cause a shift in immune function from the Th1 side (acute inflammatory discharging response) to the Th2 side (chronic auto-immune or allergic response). 6

 

The outcome of this line of thought is that, contrary to previous belief, vaccinations do not strengthen or "boost" the whole immune system. Instead vaccinations overstimulate the "tasting and remembering" function of the antibody-mediated branch of the immune system (Th2) which simultaneously suppresses the cellular immune system (Th1) thus "preventing" the disease in question.

 

What in reality is prevented is not the disease but the ability of our cellular immune system to manifest, to respond to and to overcome the disease!

 

There is no system of the human being, from mind to muscles to immune system, which gets stronger through avoiding challenges, but only through overcoming challenges. The wise use of vaccinations would be to use them selectively, and not on a mass scale. In order for vaccinations to be helpful and not harmful, we must know beforehand in each individual to be vaccinated whether the Th1 function or the Th2 function of the immune system predominates.

 

In individuals in whom the Th1 function predominates, causing many acute inflammations because the cellular immune system is overreactive, a vaccination could have a balancing effect on the immune system and be helpful for that individual.

 

In individuals in whom the Th2 function predominates, causing few acute inflammations but rather the tendency to chronic allergic or autoimmune inflammations, a vaccination would cause the Th2 function to predominate even more, aggravating the imbalance of the immune system and harming the health of that individual. This is what happened in Gulf War Illness.

 

The current use of vaccinations in medicine today is essentially a "shotgun" approach which ignores differences among individuals. In such an approach some individuals may be helped and others may be harmed.

 

If medicine is to evolve in a healthy direction, we must learn to understand the particular characteristics of each individual and we must learn how to individualize our treatments to be able to heal each unique human being in our care.

 

Based on the preceding explanation of how vaccinations work, here are my answers to your questions:

 

Vaccinations are usually effective in preventing an individual from manifesting a particular illness, but they do not improve the overall strength or health of the individual nor of the immune system. Instead, vaccinations modify the reactivity of the immune system, decreasing acute discharging inflammatory reactions and increasing the tendency to chronic allergic and auto-immune reactions.

 

Epidemiologic studies 7 8 9 have shown that as families improve their living conditions, hygiene, nutrition, literacy and education, the risk of life-threatening acute infectious , inflammatory diseases very much decreases. Families with poor living conditions, hygiene, nutrition and literacy would generally be most likely to benefit from vaccinations. Families with good living conditions, hygiene, nutrition and education probably would benefit from vaccinations very little or not at all. Individuals with a tendency to allergic or auto-immune diseases are likely to be harmed by vaccinations.

 

Side effects of vaccination are usually allergic or auto-immune inflammatory reactions caused by the shift of the immune system’s reactivity from the Th1 side to the Th2 side. Modern medicine is just beginning to recognize this. 10

 

Modern medicine has not scientifically measured the risk/benefit ratio of any vaccine. 11 Research into the risks of vaccines is very inadequate, according to two comprehensive reports on vaccines by the U.S. Institute of Medicine in 1991 and 1994.

 

My preceding explanation of how vaccinations affect the immune system is true also in animals. Vaccinations cannot make animals healthier, but only good handling, environment and nutrition can make animals healthy and resistant to disease. Vaccinating pigs may prevent them from having illness from one particular strain of virus but will not improve their overall resistance to other illnesses nor even to other strains of the same virus.

 

It is important to remember that an infection with a particular virus or bacterium does not necessarily cause illness unless the resistance of the individual is low. In the case of Japanese Encephalitis Virus (JEV), most infections cause no symptoms and fewer than 0.1% of infected individuals develop severe encephalitis. 12 Individuals living in poor conditions, with poor hygiene, nutrition and education are at higher risk of serious illnesses from JEV or any other infection. In such individuals a vaccination would most likely be helpful.

 

Each individual should inform himself or herself: just how widespread is the disease outbreak? How many have become seriously ill or died? Does the outbreak affect all levels of society or mainly those in poor living conditions?

 

Very often the media exaggerate the extent of such outbreaks. Each individual should freely decide, based on knowledge and not on fear and hearsay, whether he or she or a child would benefit from a vaccination.

 

Philip F. Incao, M.D.

 

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  • Epigenetics - I couldn't agree more. I was delighted when I found this article as like you I had had all these ideas about vaccines in the back of my mind for a while and Dr. Incao has described them perfectly. I am hoping better delivery systems for vaccines (such as in probiotic bacteria - as described in this article) will go some way to increasing the accuracy of the vaccination "shot gun". Ideally we need effective screening before vaccinations are given to avoid giving them to those susceptible to adverse reactions.

    RT - Vaccinations can potentially make us ill in a variety of ways. The doctor who wrote this article suspects they cause a shift in how the immune system works in some people that makes them more susceptible to allergies and chronic illnesses such as autoimmune disease, chronic fatigue syndrome and Gulf War syndrome. Some people also have allergic reactions to the vaccines themselves. This would cause symptoms to appear quickly after the shot. Other possible causes of illnesses after vaccinations include reactions to mercury preservatives (thimerosal) and other additives such as aluminium hydroxide although these are still vigourously debated.

    Like 0 Short URL:
  • Guest - Olivia

    This is an interesting article, but leaves out one major problem with vaccines. Not really the disease that is in the vaccine but the other HARMFUL ingredients. Animal DNA, mercury, aluminum, formaldehyde, the list goes on. Let your body fight the disease if you happen to get it and you will be stronger in the long run. History has shown that diseases that we immunize against were on their way out before the vaccine was ever introduced.

    Like 0 Short URL:
  • Absolutely Olivia, vaccines contain numerous suspect additives used as preservatives and adjuvants that in theory might have undesirable effects...completely aside from the immune dysfunction caused by the vaccine itself as proposed in this article.

    I would however caution against shunning vaccinations completely however. They have undoubtedly saved lives and the majority of people will tolerate them without serious adverse effect. I frequently tell anyone who will listen that what we need is a more individualised approach. Yes, use vaccines (without the added nasties) to control infectious disease but develop methods to screen for those who might be most at risk of adverse reactions. More basic biomedical research into the effects of vaccines on the immune system (long-term) would not go amiss either. Most research into vaccines is epidemiological and if most people don't have rapid and serious reactions then a vaccine is deemed safe!

    Like 0 Short URL:
  • Guest - JH, DC

    Great article.
    Many of my colleagues are anti-vaccination. As a health-care provider I think it is completely reckless to encourage people not to vaccinate. If parents think they have healthier kids from only NOT vaccinating and live and eat the typical American diet, you are asking for trouble.
    Adjuvants and other "nasties" are put in vaccines to ramp up the immune response. Therefore, until those change, I will steer clear for my family. I LOVE the idea of possibly using a "probiotic" type vector to introduce the good aspects of immunizations. Great idea.

    Like 0 Short URL:
  • I agree JH. All too often this debate is completely polarised when what we really need is to find a sensible (and safe!) middle path. Yes we need vaccines to prevent serious infectious diseases, but the effects of adjuvants need to be looked at more carefully and there needs to be more focus on the individual. Some people are clearly more susceptible to adverse vaccine reactions than others and we need to know who will react badly BEFORE the vaccinations are given.
    I also love the idea of using probiotic bacteria as a vector for vaccines. The GI tract is a more natural route for antigens to be introduced to the body after all! If you haven't already, take a look at this news article - Probiotics may offer more effective and less painful vaccinations

    Like 0 Short URL:
  • Guest - Clark Baker

    We know that infectious disease became statistically irrelevant before the drug industry began to market vaccines. Although the CDC ostensibly wants to protect the American herd with vaccinations, a responsible agency would first produce a large retrospective study of vaccinated and unvaccinated populations to compare the risks and benefits of vaccinations.

    The fact that this was never done suggests that the CDC is more concerned about drug manufacturers. This is what criminal investigators recognize as consciousness of guilt – they don’t WANT to know.

    Understandably, industry attorneys will warn their clients (drug companies) not to conduct ANY study unless the outcome is known or can be manipulated.

    This should surprise no one. What can we expect from an industry that has paid $9 billion (since 2004) to settle thousands of criminal and civil complaints related to the illegal marketing of drugs that kill or injure a million Americans every year?

    Like 0 Short URL:
  • Guest - Robyn Newberry

    This is a fabulous article! I'm so happy to have read it. I am currently immersed in the whole vaccination debate. My son is 10 months old and still not vaccinated. He is breastfed and stays home with his dad. However, we live in the United Arab Emirates. While most kids here are vaxed it is still the Middle East! Additionally, we are thinking about enrolling him in a small preschool next year. These factors taken into account have prompted me to seriously consider some vaccinations.

    What is your take on the Oral Polio vaccine. It's still used here in the UAE. I have some concerns that my son could get VAPP from another child. This has put the polio vaccine high on the potential list. However, the monkey kidney cultures certainly give me pause!

    Any opinions on living overseas without vaccinations, as well as group childcare (while still breastfeeding) would be greatly appreciated!

    LOVE this conversation....THANK YOU!!

    Like 0 Short URL:
  • Guest - jon45

    Maff, we don't need vaccines to prevent infectious diseases because they don't actually prevent infectious disesases. I have read hundreds if not thousands of medical papers and no study has ever shown vaccines prevent disease even though they like to write in the conclusion that they did. The diseases you're thinking of were all but completely gone before vaccines were even sold. Diseases that didn't have vaccines also disappeared. Countries that didn't promote vaccines saw the same diseases disappear as well. I've seen many infecious disease doctors, GPs, Immunologist, etc and none of them have ever read a single vaccine study, not one. They read their textbooks, which i've also read, and their textbooks show disease rates in 1910, then the rates in 1990 and claim vaccines made all the difference. They strategically manipulate doctors into believing lies by leaving out the data for the years in between.

    Like 0 Short URL:
  • Guest - Andria Myers

    Dr. I could kiss you right now. I love Doctors who really care about the health of their patients and not the amount of money in the bank. God bless you. I wish I could find a pediatrician like you in my area.
    My infant developed ugly rash a week after vaccination, it looked like a burn along with very dry skin on both lower legs. After the second series of shots, the rash got progressively worse, now on legs, arms, back, abdomen, neck, jaw. I Found out weeks after that my son has atopic dermatitis, and that rash that resembles a burn, turned out to be numular type eczema. My son has had 3-4 ear infections, bronchiolitis a month after his first rounds of pentacel and prevnar 13. I told his doctors, they look at me as if i am uneducated when i claim that my son's eczema and hypersensitivites are a result from vaccinations. But, i am not uneducated. I am also in the medical field. I am not a doctor, but with further education, I could be, if I want to. Relentless research led me to believe that my son's eczema is in fact a result of prevnar13 and pentacel. I will hold steadfast to my claim. I too was brainwashed in school to believe that vaccines are 100% safe and effective. It is not until my son had the reactions which lead to my tireless research. I have held off on vaccines for months now. The eczema is there still, but not as terrible as it once was. Evidence of numular eczema, are on bilateral sholders, on abdomen on feet and behind knee. But, thank God, i can say that it is looking better.So, I believe that is immune system (the TH2 portion of it) is calming down. I pray to God it will go back to normal completely, and he will be cured of his eczema.
    I came across you article and I am in full support of it, as I also know that it is true. Thank you.
    Give yourself a kiss for me.

    Like 0 Short URL:
  • Guest - Aj09

    This type of article is great to read as a parent of two children under 3. I've spent the last 3 years trying to learn the other side of the argument since you only hear one side at the pediatrician. I've been treated horribly when I ask questions and so it's a difficult position to be in. You mention that some vaccines would be beneficial, so how do parents get correct information on what vaccines would be ok? Or if you don't vaccinate your children, what are specific things to do to protect them? I just feel like I have to be well armed since you get attacked as a parent if you don't continue with the disturbing vaccination schedule.

    Like 0 Short URL:
Comments (12)Add Comment
0
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written by epigenitics, July 06, 2009
Once again maff, thanks for the link, I skimmed it the first time and I just finished reading it a second and it basically sums up most of my concerns about vaccines and the immune system. I pretty much have everything Dr. Incao says on a back burner in my brain and it is driving me crazy.

I read a neuroimmunology article that was saying pretty much the same thing about increased Th2 and Th 1(Th2>>>Th1) activation in autistic children and little IL-10 compensation in comparison to control children.
Elevated cytokine levels in children with autism spectrum disorder
Molloy et al. 2005
And they concluded:
Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.

My son had atopic eczema when he was younger, likely caused by a Th2 response to food allergies or his environment. My youngest son who is too young to tell if he is autistic has atopic eczema as well(and hasn't been to his first vaccination), so I am scared to vaccinate him cause I consider him at high risk already having immune/allergy issues. My oldest(3rd) son had speech delays but never atopic eczema and he is not autistic.
Honestly I and most sensible people don't think vaccines cause brain damage in healthy people, but there are subgroups of the population that are going to be environmentally susceptible, it can't be avoided. I have found several studies that indicate atopic eczema(Th2 immune response) to be very prevalent in autistic children.

Honestly Dr. Incao said it so well, every single person is so incredibly unique in their genetic make up and vaccines are basically a shotgun with little accuracy or consideration for variability or susceptibility in the population. And then we wonder why swine flu is killing more children than adults. I just wonder how long we can ignore what we know and science is telling us, Until autism is 1 in 10 and variants of the rhinovirus begin to start killing people?
0
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written by rt, October 31, 2009
hi how to vaccinations make us ill
Maff
...
written by Matthew Hogg, November 02, 2009
Epigenetics - I couldn't agree more. I was delighted when I found this article as like you I had had all these ideas about vaccines in the back of my mind for a while and Dr. Incao has described them perfectly. I am hoping better delivery systems for vaccines (such as in probiotic bacteria - as described in this article) will go some way to increasing the accuracy of the vaccination "shot gun". Ideally we need effective screening before vaccinations are given to avoid giving them to those susceptible to adverse reactions.

RT - Vaccinations can potentially make us ill in a variety of ways. The doctor who wrote this article suspects they cause a shift in how the immune system works in some people that makes them more susceptible to allergies and chronic illnesses such as autoimmune disease, chronic fatigue syndrome and Gulf War syndrome. Some people also have allergic reactions to the vaccines themselves. This would cause symptoms to appear quickly after the shot. Other possible causes of illnesses after vaccinations include reactions to mercury preservatives (thimerosal) and other additives such as aluminium hydroxide although these are still vigourously debated.
0
...
written by Olivia, January 07, 2011
This is an interesting article, but leaves out one major problem with vaccines. Not really the disease that is in the vaccine but the other HARMFUL ingredients. Animal DNA, mercury, aluminum, formaldehyde, the list goes on. Let your body fight the disease if you happen to get it and you will be stronger in the long run. History has shown that diseases that we immunize against were on their way out before the vaccine was ever introduced.
Maff
...
written by Matthew Hogg, January 07, 2011
Absolutely Olivia, vaccines contain numerous suspect additives used as preservatives and adjuvants that in theory might have undesirable effects...completely aside from the immune dysfunction caused by the vaccine itself as proposed in this article.

I would however caution against shunning vaccinations completely. They have undoubtedly saved lives and the majority of people will tolerate them without serious adverse effect. I frequently tell anyone who will listen that what we need is a more individualised approach. Yes, use vaccines (without the added nasties) to control infectious disease but develop methods to screen for those who might be most at risk of adverse reactions. More basic biomedical research into the effects of vaccines on the immune system (long-term) would not go amiss either. Most research into vaccines is epidemiological and if most people don't have rapid and serious reactions then a vaccine is deemed safe!
0
...
written by JH, DC, March 18, 2011
Great article.
Many of my colleagues are anti-vaccination. As a health-care provider I think it is completely reckless to encourage people not to vaccinate. If parents think they have healthier kids from only NOT vaccinating and live and eat the typical American diet, you are asking for trouble.
Adjuvants and other "nasties" are put in vaccines to ramp up the immune response. Therefore, until those change, I will steer clear for my family. I LOVE the idea of possibly using a "probiotic" type vector to introduce the good aspects of immunizations. Great idea.
Maff
...
written by Matthew Hogg, March 19, 2011
I agree JH. All too often this debate is completely polarised when what we really need is to find a sensible (and safe!) middle path. Yes we need vaccines to prevent serious infectious diseases, but the effects of adjuvants need to be looked at more carefully and there needs to be more focus on the individual. Some people are clearly more susceptible to adverse vaccine reactions than others and we need to know who will react badly BEFORE the vaccinations are given.
I also love the idea of using probiotic bacteria as a vector for vaccines. The GI tract is a more natural route for antigens to be introduced to the body after all! If you haven't already, take a look at this news article - Probiotics may offer more effective and less painful vaccinations
0
...
written by Clark Baker, April 03, 2011
We know that infectious disease became statistically irrelevant before the drug industry began to market vaccines. Although the CDC ostensibly wants to protect the American herd with vaccinations, a responsible agency would first produce a large retrospective study of vaccinated and unvaccinated populations to compare the risks and benefits of vaccinations.

The fact that this was never done suggests that the CDC is more concerned about drug manufacturers. This is what criminal investigators recognize as consciousness of guilt – they don’t WANT to know.

Understandably, industry attorneys will warn their clients (drug companies) not to conduct ANY study unless the outcome is known or can be manipulated.

This should surprise no one. What can we expect from an industry that has paid $9 billion (since 2004) to settle thousands of criminal and civil complaints related to the illegal marketing of drugs that kill or injure a million Americans every year?
0
...
written by Robyn Newberry, June 08, 2011
This is a fabulous article! I'm so happy to have read it. I am currently immersed in the whole vaccination debate. My son is 10 months old and still not vaccinated. He is breastfed and stays home with his dad. However, we live in the United Arab Emirates. While most kids here are vaxed it is still the Middle East! Additionally, we are thinking about enrolling him in a small preschool next year. These factors taken into account have prompted me to seriously consider some vaccinations.

What is your take on the Oral Polio vaccine. It's still used here in the UAE. I have some concerns that my son could get VAPP from another child. This has put the polio vaccine high on the potential list. However, the monkey kidney cultures certainly give me pause!

Any opinions on living overseas without vaccinations, as well as group childcare (while still breastfeeding) would be greatly appreciated!

LOVE this conversation....THANK YOU!!
0
...
written by jon45, January 01, 2012
Maff, we don't need vaccines to prevent infectious diseases because they don't actually prevent infectious disesases. I have read hundreds if not thousands of medical papers and no study has ever shown vaccines prevent disease even though they like to write in the conclusion that they did. The diseases you're thinking of were all but completely gone before vaccines were even sold. Diseases that didn't have vaccines also disappeared. Countries that didn't promote vaccines saw the same diseases disappear as well. I've seen many infecious disease doctors, GPs, Immunologist, etc and none of them have ever read a single vaccine study, not one. They read their textbooks, which i've also read, and their textbooks show disease rates in 1910, then the rates in 1990 and claim vaccines made all the difference. They strategically manipulate doctors into believing lies by leaving out the data for the years in between.
0
...
written by Andria Myers, September 11, 2012
Dr. I could kiss you right now. I love Doctors who really care about the health of their patients and not the amount of money in the bank. God bless you. I wish I could find a pediatrician like you in my area.
My infant developed ugly rash a week after vaccination, it looked like a burn along with very dry skin on both lower legs. After the second series of shots, the rash got progressively worse, now on legs, arms, back, abdomen, neck, jaw. I Found out weeks after that my son has atopic dermatitis, and that rash that resembles a burn, turned out to be numular type eczema. My son has had 3-4 ear infections, bronchiolitis a month after his first rounds of pentacel and prevnar 13. I told his doctors, they look at me as if i am uneducated when i claim that my son's eczema and hypersensitivites are a result from vaccinations. But, i am not uneducated. I am also in the medical field. I am not a doctor, but with further education, I could be, if I want to. Relentless research led me to believe that my son's eczema is in fact a result of prevnar13 and pentacel. I will hold steadfast to my claim. I too was brainwashed in school to believe that vaccines are 100% safe and effective. It is not until my son had the reactions which lead to my tireless research. I have held off on vaccines for months now. The eczema is there still, but not as terrible as it once was. Evidence of numular eczema, are on bilateral sholders, on abdomen on feet and behind knee. But, thank God, i can say that it is looking better.So, I believe that is immune system (the TH2 portion of it) is calming down. I pray to God it will go back to normal completely, and he will be cured of his eczema.
I came across you article and I am in full support of it, as I also know that it is true. Thank you.
Give yourself a kiss for me.
0
...
written by Aj09, January 28, 2013
This type of article is great to read as a parent of two children under 3. I've spent the last 3 years trying to learn the other side of the argument since you only hear one side at the pediatrician. I've been treated horribly when I ask questions and so it's a difficult position to be in. You mention that some vaccines would be beneficial, so how do parents get correct information on what vaccines would be ok? Or if you don't vaccinate your children, what are specific things to do to protect them? I just feel like I have to be well armed since you get attacked as a parent if you don't continue with the disturbing vaccination schedule.

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Last Updated on Thursday, 17 March 2011 12:08
 

 

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