MTHFR and COMT SNPs and what they mean for your health

Discussion started by Maff , on Thursday, 16 June 2011 18:49

Hi all,

 

Last year I had genomic testing done for common SNPs including MTHFR, MTRR and COMT - all vital for influencing enzymes involved in the methylation cycle.

 

My SNP results showed I am homozygous for MTHFR (C677T & A1298C), MTRR (A66G) and COMT (V158M) - so essentially the worst combination of gene variants in terms of methylation capacity...

 

For a bit of context I was diagnosed with M.E./Chronic Fatigue Syndrome 20 years ago at the age of 12. I also suffer badly from adrenal fatigue and mood and sleep problems.

 

After getting my results I did a lot of research and that went a long way to explaining why I would suffer from these secondary conditions in addition to ME/CFS. These papers will make interesting reading for anyone with these SNPs, heterozygous or homozygous...so I wanted to share them. Take a look:

 

1. http://www.ei-resource.org/comt-stress-response.pdf

2. http://www.ei-resource.org/mthfr-huge-review.pdf

 

If anyone wants to share their SNP results relating to the methylation cycle and what illnesses/symptoms they suffer from that would be great!

 

 

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