Dr. Damien Downing M.D. is President of the British Society for Ecological Medicine (www.ecomed.org.uk), Chief Medical Advisor to the charity Yes to Life (www.yestolife.org.uk), and Editorial Board member of the Orthomolecular News Service (www.orthomolecular.org). He is a practitioner of ecological medicine in London (www.newmedicinegroup.com) and York (www.naltd.co.uk) and author of several books including The Vitamin Cure for Allergies (USA, Basic Health Books, 2010).
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Thursday, May 12th, 2011:
Although it has often been said to have no clinical significance, this does not explain why Gilbert’s “sufferers” are relatively common among our patients. It is likely that such people are more vulnerable to adverse effects of physical, particularly hepatotoxic, stress. Indeed, stress tests have been used to confirm the diagnosis (calorie restriction to 400/day; intravenous nicotinic acid; oral Rifampicin); all these raise the bilirubin by competing for the role of substrate to the limited enzyme. Those with Gilbert’s do seem to exhibit symptoms more often than is the norm after infections, toxic exposures and the like. It is probable that they are more vulnerable to, for instance, the potentially severe consequences of paracetamol toxicity.
Glucuronidation detoxifies all of the following molecules:
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|Last Updated on Thursday, 12 May 2011 12:11|