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TOPIC: Testing for Adrenal Fatigue

Re:Testing for Adrenal Fatigue 9 years 6 months ago #13

  • Maff
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Hi David,

Good to hear from you. The snow outside may have all but gone but I am still snowed under with final year degree work and of course maintaining the website. I'm battling on though!

I'm glad you finally got your ASI results and they provided you with some useful information to go on. DHEA levels are reportedly the first to decline so your low DHEA-S and normal cortisol suggest you may be in the early stages of adrenal fatigue. This is good news and DHEA replacement should certainly help. It's when your cortisol levels start to go out that you get major problems.

Although there is little to no long-term data on how taking supplements of either prenenolone or DHEA affect the body's own production it is fairly safe to say that dosages up to 25mg per day are quite safe. There doesn't seem to be the major suppression of the body's own production that is seen with the conventional steroid medications (cortisol). Nevertheless my advise would be that you stop the pregnenolone and just take 25mg DHEA and see how you do. Keep in mind that the effects of hormone treatment tend to increase over time. You may find that after a month or two you can reduce to half that amount and still feel the same benefits.

My personal experience is that I took 25mg of DHEA and began to feel better within a week. After a few more weeks I was feeling a lot better at which point the improvements levelled off. I then found I could reduce to 12.5mg every other day and still maintain the benefits.

Taking as little as possible to feel well is the aim with hormones as they are powerful substances and not to be used lightly. Keep an eye out for any side-effects. I personally had a problem with liver toxicity after a few months on DHEA but my liver was already in very bad shape and this shouldn't be a problem for the vast majority of people at 25mg and below. It has only shown up in animal studies at the equivalent of 1000mg per day!

I'm pleased you were happy with Dr. Myhill and her staff. They have always been very good to me and they get things turned around very quickly!

What was the problem at the lab? I hope you didn't have to send another set of samples!

Good luck with the DHEA :)
If you are going through hell, keep going - Winston Churchill
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Re:Testing for Adrenal Fatigue 9 years 6 months ago #14

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Hi there. Good good luck with your studies! Thanks for the reply. I think I'll slowly reduce the Preg then and see how it goes. They didn't say what the problem was at the lab but luckily I didn't have to do more samples! I'll report on my progress after a couple of weeks (hope this may help others)
Cheers, thanks again Maff. Your help has been invaluable.
David
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Re:Testing for Adrenal Fatigue 9 years 6 months ago #15

  • Maff
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Thanks David. I might not be working on the site so much over the coming months in order to get my dfegree work finished but I'll get there I'm sure! Be sure that I'll still be reading all forum and blog posts by members even if I don't get chance to reply ;)

Glad you didn't have to send extra samples and it would be great to get an update on your progress. I'm sure others will benefit from your experience.

No problem, happy to help as much as I can!
If you are going through hell, keep going - Winston Churchill
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Re:Testing for Adrenal Fatigue 9 years 6 months ago #16

You mentioned that your DHEA supplementation exasperated some preexisting liver problems for you.
1) What were your preexisting liver problems?
2) How did you discover/determine the liver exasperation?
3) How did you change your regimen?

T.R. Morris, ND
May you be well!

Dr. Timothy R. (T.R.) Morris
Naturopathic Medical Doctor
trmorrisnd.com/
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Re:Testing for Adrenal Fatigue 9 years 6 months ago #17

  • Maff
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Hi Timothy,

I don't have a formal diagnosis of liver disease other than assumed \"toxic hepatitis\".

I was diagnosed with chronic fatigue syndrome nearly 19 years ago aged 12. I subsequently developed severe intestinal Candidiasis/fungal-type dysbiosis (whatever we are calling it now) due to the immune dysfunction associated with CFS.

These gut problems were diagnosed by various integrative medicine practicing MDs and a specialist gastroenterologist using CDSA (Genova Diagnostics), Gut Fermentation Profile (Biolab UK), Candida antibodies (Genova Diagnostics), and Intestinal Permeability Profiles (Biolab UK) - in conjunction with history and symptoms.

Evidence of liver toxicity include signs of mild inflammation/enlargment on ultrasound, elevated GGT (in absence of alcohol consumption or drug use), AST and ALT towards high end of normal, cytochrome P450 isoenzyme patterns indicative of chronic ethanol or paracetemol exposure (again in absence of exogenous sources), elavated D-glucaric acid, depleted cysteine and GSH.

These were present before I used DHEA but following use at 25mg/d for a couple of weeks I began to see marked symptoms of liver toxicity including jaundice, abdominal pain following bowel movements, general fatigue/flu-like feeling (distinguishable from baseline symptoms) steatorrhoea, and progressively worsening pathological changes in stool colour from light brown to tan to grey/white.

I had previously had the same reaction to a week's course of ciprofloxacin at 500mg bid.

ALso notable is my seeming inability to detoxify acetaldehyde. I rapidly develop symptoms of severe alcohol induced hangover following ingestion of high carb foods or minute amounts of alcoholic beverages. I have as yet not had my aldehyde dehydrogenase activity or related gene expression evaluated but I strongly suspect abnormalities there.

In terms of supporting liver function I have had good success with choleretic herbs (particularly Tribulus terrestris) along with high phosphatidylcholine lecithin, silymarin, and mineral cofactors for GSH peroxidase (selenium) and SOD (zinc, copper, manganese). I also supply sulphur using epsom salt baths/footbaths.

The following are studies finding Tribulus terrestris to be hepatoprotective and effective at increasing reduced GSH and reduxing lipid peroxidation:

http://www.apocp.org/cancer_download/Volume7_No2/Manish%20Kumar.pdf

http://www.ncbi.nlm.nih.gov/pubmed/17436531

Many more are easily located in the literature. Although the evidence would currently be considered weak my personal experience is that this is the best hepatoprotective and glutathione promoting herb.

This approach has mitigated my symptoms but not healed my liver as I am still struggling with attempts to restore my gut microbiota to a healthy composition and restore mucosal barrier function.

I hope this provides some insight.
If you are going through hell, keep going - Winston Churchill
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Re:Testing for Adrenal Fatigue 9 years 5 months ago #18

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Hi Maff
Me again. Hope your studies etc going ok. Me not doing too well. Nearly 6 weeks on the DHEA. Very little improvement unfortunately. Mega anxiety and brain fogginess still a real problem. Not well enough to see my way out of my work situation which needs to change to tackle the root of the chronic fatigue. Will retest DHEA levels next week. Do you think Dr Myhill will up my dose?
Best regards
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