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- Bushi
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- EiR Senior
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Mild Terminal Ileitis and SIBO: what does it mean?
Hi all,
I was hoping someone may be able to enlighten me as i can't seem too much clear info on it.
I was recently re-confirmed with SIBO for which i am on a 12 week course of antibiotics.
However, the MRI small bowel scan showed non specific 'mild terminal ileitis'. But it goes on to say that the ileum was normal on the colonoscopy and ileal biopsies were also normal.
Any ideas what this means?
Thanks all!
I was hoping someone may be able to enlighten me as i can't seem too much clear info on it.
I was recently re-confirmed with SIBO for which i am on a 12 week course of antibiotics.
However, the MRI small bowel scan showed non specific 'mild terminal ileitis'. But it goes on to say that the ileum was normal on the colonoscopy and ileal biopsies were also normal.
Any ideas what this means?
Thanks all!
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- Maff
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- Administrator
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- Thank you received: 6
Re: Mild Terminal Ileitis and SIBO: what does it mean?
Hi Bushi,
My best educated guess would be that the overgrowth of gut bacteria (i.e. SIBO) might be causing chronic low-level inflammation of terminal ileum (very bottom of the small intestine). This could be through direct contact with the gut wall or result of toxins produced by the high bacterial populations.
The following research findings might be of interest here. I am sure you can connect the dots!
Small intestinal bacterial overgrowth (SIBO) common in irritable bowel syndrome
Irritable bowel syndrome result of low level inflammation of gut wall
Good luck with the antibiotic treatment. Which antibiotic are have you been prescribed out of interest?
Take care
My best educated guess would be that the overgrowth of gut bacteria (i.e. SIBO) might be causing chronic low-level inflammation of terminal ileum (very bottom of the small intestine). This could be through direct contact with the gut wall or result of toxins produced by the high bacterial populations.
The following research findings might be of interest here. I am sure you can connect the dots!
Small intestinal bacterial overgrowth (SIBO) common in irritable bowel syndrome
Irritable bowel syndrome result of low level inflammation of gut wall
Good luck with the antibiotic treatment. Which antibiotic are have you been prescribed out of interest?
Take care
If you are going through hell, keep going - Winston Churchill
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- Bushi
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- EiR Senior
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- Posts: 43
- Karma: 1
- Thank you received: 2
Re: Mild Terminal Ileitis and SIBO: what does it mean?
Thanks for the info as always Maff!
The two antibiotics i have been given are ciproflaxacin and Metrozonidole (Flagyl).
I've have two take each one for two weeks alternating them for a total of 12 weeks. I've into week 6 now but can't really say i've noticed a difference unfortunately. I can't see another 6 weeks doing very much but I will stick with it.
I've also been alternating with Enteric Coated Peppermint Capsules and Oil of Oregano. And also Colostrum.
Nothing seems to bring relief!!!! GRrrrrr!!
I've also been reading about Bile Acid Diarrhea so I plan to run a SeHCAT test. Not many hospitals run the test but I've found one that does and hope to get referred.
Check out this article:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3002596/
"Using these figures we have estimated the population prevalence of bile acid diarrhoea. There are up to 3.9 million adults in the UK being treated for IBS, approximately 10% of the population. With one third of these having IBS-D, and one third of those having idiopathic BAM, we estimate the prevalence in the general population of this condition to be over 1% overall. This means there are a possible 500,000 people in the UK, and many millions of people in the Western world, that have this condition, exceeding better known conditions such as Crohn's or ulcerative colitis, which have prevalence figures of about 0.2% and 0.3% respectively, and broadly similar to coeliac disease. It is clearly incorrect to think of this as a rare cause of IBS: a myth which unfortunately is still mistakenly held"
and here's a wikipedia description:
en.wikipedia.org/wiki/Bile_acid_malabsorption
The two antibiotics i have been given are ciproflaxacin and Metrozonidole (Flagyl).
I've have two take each one for two weeks alternating them for a total of 12 weeks. I've into week 6 now but can't really say i've noticed a difference unfortunately. I can't see another 6 weeks doing very much but I will stick with it.
I've also been alternating with Enteric Coated Peppermint Capsules and Oil of Oregano. And also Colostrum.
Nothing seems to bring relief!!!! GRrrrrr!!
I've also been reading about Bile Acid Diarrhea so I plan to run a SeHCAT test. Not many hospitals run the test but I've found one that does and hope to get referred.
Check out this article:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3002596/
"Using these figures we have estimated the population prevalence of bile acid diarrhoea. There are up to 3.9 million adults in the UK being treated for IBS, approximately 10% of the population. With one third of these having IBS-D, and one third of those having idiopathic BAM, we estimate the prevalence in the general population of this condition to be over 1% overall. This means there are a possible 500,000 people in the UK, and many millions of people in the Western world, that have this condition, exceeding better known conditions such as Crohn's or ulcerative colitis, which have prevalence figures of about 0.2% and 0.3% respectively, and broadly similar to coeliac disease. It is clearly incorrect to think of this as a rare cause of IBS: a myth which unfortunately is still mistakenly held"
and here's a wikipedia description:
en.wikipedia.org/wiki/Bile_acid_malabsorption
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- Maff
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- Administrator
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- Thank you received: 6
Re: Mild Terminal Ileitis and SIBO: what does it mean?
You're welcome Bushi. I wanted to thank you for all the great information you've posted in blogs and in the forums lately, interesting reads and much appreciated!
Metrozonidole is an obvious option for the SIBO but is there any specific reason why ciprofloxacin was chosen? It is pretty toxic stuff - I took a 10 day course after a CDSA sensitivity test indicated it would get rid of the undersirable bacteria my gut harboured. The result was toxic hepatitis and no improvement in gut health. Others have reported to me that extended courses of cipro were the initial trigger for them developing MCS. Not trying to scare you, just wanted you to be aware! If you haven't had any adverse reaction after 6 weeks I'd imagine you'll be fine with it.
Anyway, I'm sorry nothing seems to be improving your problems. I can't remember if you've tried rifaximin in the past for the SIBO? I reported on a preliminary study involving IBS patients with SIBO this week that found 7 days of rifaximin followed by 10 days of probiotics brought dramatic improvement in both lactulose breath test score and symptoms in 14/15 participants - not a big enough study to conclude anything but encouraging. Article here
The bile acid diarrhea abstract is interesting. I have always focused my attention on stimulating production of bile acid by the liver but it's very likely that I, and many others, have problems reabsorbing bile acids from the gut due to gut dysbiosis, mucosal inflammation etc. Let us know if you get the test done and what the results are!
Metrozonidole is an obvious option for the SIBO but is there any specific reason why ciprofloxacin was chosen? It is pretty toxic stuff - I took a 10 day course after a CDSA sensitivity test indicated it would get rid of the undersirable bacteria my gut harboured. The result was toxic hepatitis and no improvement in gut health. Others have reported to me that extended courses of cipro were the initial trigger for them developing MCS. Not trying to scare you, just wanted you to be aware! If you haven't had any adverse reaction after 6 weeks I'd imagine you'll be fine with it.
Anyway, I'm sorry nothing seems to be improving your problems. I can't remember if you've tried rifaximin in the past for the SIBO? I reported on a preliminary study involving IBS patients with SIBO this week that found 7 days of rifaximin followed by 10 days of probiotics brought dramatic improvement in both lactulose breath test score and symptoms in 14/15 participants - not a big enough study to conclude anything but encouraging. Article here
The bile acid diarrhea abstract is interesting. I have always focused my attention on stimulating production of bile acid by the liver but it's very likely that I, and many others, have problems reabsorbing bile acids from the gut due to gut dysbiosis, mucosal inflammation etc. Let us know if you get the test done and what the results are!
If you are going through hell, keep going - Winston Churchill
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