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TOPIC: Methyl cycle defects & DNA testing

Methyl cycle defects & DNA testing 6 years 1 month ago #1

  • Jodie
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I am posting this (with permission) from another group as I thought it was so interesting...


"....I chose to focus on looking for methyl cycle defects. I did everything
else I could think of, addressing the no-onoo- cycle, nutritionally
addressing detox pathways, going on a candida diet and cleaning up the
candida, repopulating my gut micro flora. avoiding chemicals as much as
humanly possible...

And while i made a lot of improvement over the years I could not get
past severe sensitivities to even small exposures most, if not many times.

Then, my Twin and myself looked into methyl cycle defects, and had dna
testing done through 23andme.com

Low and behold, we had defects in almost every part of the methyl cycle!!

Because we both have studied nutrition and biochemistry, we did lots of
research while waiting for the test results to come back, and we made
some educated guesses as to what methyl cycle defects we might have
based on our ethnicity and long term symptoms and decided to try adding
an activated reduced form of folate, methionine and extra choline to our
supplement list and changing some of the supplements we were taking

The results were worth the changes. although there is a type of
sensitive period when the enzymes get turned on and the body starts
cleaning up old infections and detoxing. And we had to do this very
slowly or the symptoms and reactions were serious

Turns out we made some pretty good guesses. When the results came back
we didn't change a thing, but we were quite surprised at how many
polymorphisms we had! The night I added a methione supplement, my
histamine headaches were cut in half.

As it turns out, anywhere from 40 to 60 percent of the population has an
Mthfr polymorphism, sometimes with other methyl cycle defects.

Addressing mthfr issues is not a cure for mcs, and I still have pretty
bad. but for me it is was one more missing piece of the sickness
puzzle. And for those it affects, it can be a key missing piece.
This cycle has a lot to do with making key neurotransmitters, DNA
repair, detoxing, BH4, and immune system functioning among other functions.

For Anyone interested in looking at this issue for themselves here are
some websites to explore.

mthfr.net/ (the video on this site is Quite good.)

drmyhill.co.uk/wiki/CFS_-_The_Methylation_Cycle

www.mthfrsupport.com/

www.heartfixer.com/AMRI-Nutrigenomics.htm

here is where we got the dna testing
www.23andme.com/

And here is where We punched in the results to get just the Mthfr defect
interpretation.

geneticgenie.org/methylation-analysis/

Hope this information helps anyone looking for more pieces of our puzzle."
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Methyl cycle defects & DNA testing 4 years 4 months ago #2

  • Maff
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Huge thanks for posting this Jodie. Methylation defects can be a huge piece of the puzzle in MCS and all of the 'invisible illnesses', as well as some very important visible illnesses like autism (see Dr. Amy Yasko's seminal work).

I myself had the common MTHFR and MTRR methylation cycle gene variants tested in 2010 - along with important cytochrome P450 (CYP) and glutathione (GSH) detoxification enzyme genes - which showed major impairment all round (see attached below). Addressing genetic deficits with the correct supplements under the supervision of a knowledgeable doctor can make a big difference.

snp-results.jpg


File Attachment:

File Name: SNPresult.pdf
File Size: 152 KB
If you are going through hell, keep going - Winston Churchill
Last Edit: 4 years 4 months ago by Maff.
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Methyl cycle defects & DNA testing 4 years 4 months ago #3

  • Jodie
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There are several Facebook sites on this for those interested - just put MTHFR into the search window in FB.
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Methyl cycle defects & DNA testing 4 years 4 months ago #4

  • Jodie
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I just realised I've posted this in the wrong place -uck! - will move it when I get min ..
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