Review Detail

 
SAMe (S-Adenosyl Methionine)
 
Overall rating 
 
8.8
Perceived Effectiveness  
 
9.0
Lack of side effects (tolerability)  
 
8.0
Ease of use  
 
9.0
Value for money  
 
8.0
Would you recommend? 
 
10.0
Reviewed by Stuart    October 26, 2009

Worked for my depression!

I count myself very lucky to have discovered SAM-e after having suffered from a form of depression for around 5 years that included a total lack of motivation and enjoyment in life. I was for all intents and purposes a zombie - a shell of a man.

My doctor fed me every antidepressant med going including SSRIs (Prozac & Zoloft), SNRIs (Venlafaxine) and even an MAOI (Parnate) and none produced any notable improvement.

Eventually I began looking into supplements and after a few failures with St. Johns Wort and other herbs I decided to see a nutritionist.

My nutritionist said the symptoms of my depression sounded like I had a deficiency of dopamine and/or norepinephrine so she suggested I try phenylalanine (an amino acid from which these are made). This produced a small but noticeable improvement. When I reported this she gave me SAM-e and - wow! After a week on 400mg per day I was really feeling like myself again for the first time in years. I actually felt like getting off my ass and doing things and the enjoyment in even the little things in life returned!

After a few months on 400mg I did notice I was becoming a bit too stimulated (which can be a common side-effect apparently) so I cut back to 300mg a day and have stuck to that without a problem for a year now.

SAM-e is quite expensive compared to other supplements but if you suffer from symptoms similar to what I have described then I would definitely say try it - it could be the key to getting your life back.

Treatment

Depression
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