A recent study sheds new light on the previously noted association between oxidative and nitrosative stress and depressive illness, pointing the finger squarely at autoimmune reactions.
The research was conducted at the Maes Clinics in Bangkok, Thailand. Michael Maes has been instrumental in establishing patterns of immune system dysfunction in chronic fatigue syndrome (ME/CFS) and other environmental illnesses and here turns his attention to the immune components of major depression.
Previously, investigators have discovered that people diagnosed with major depression have a high degree of oxidative and nitrosative stress (O&NS) in their bodies. What this means is that highly reactive molecules based on oxygen and nitrogen are present in quantities greater than their bodies can neutralize with antioxidants. O&NS is known to cause damage to cells and tissues of the body. This latest study looked at how the immune system of depressed patients responded to such damage and how this related to depressive symptoms.