A recent study finds that patients with major depressive disorder have a leaky gut and consequently inflammatory immune reactions to toxins from gut bacteria.
It is now established that an inflammatory reponse is involved in major depressive disorder (MDD). Previous research has shown that pro-inflammatory cytokines (immune chemicals) can induce depressive symptoms. It has also been discovered that lipopolysaccharide (LPS), a component of the outer membrane of certain bacteria, can do the same since it is a potent toxin which produces a strong immune response.
Researchers from M-Care4U Outpatient Clinics and the Clinical Research Center for Mental Health in Belgium wanted to build on these findings to determine if increased intestinal permeability (leaky gut) and the resulting increase in LPS in the bloodstream was associated with depression.