| Allergic memory of patients sensitized to castor bean after a long stimulation-free period |
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J Asthma. 2006 Apr;43(3):193-8.
Allergic memory of patients sensitized to castor bean after a long stimulation-free period.
Marin V, Saraga J, Ariano R, Chouquet D, Dispard M, Bongrand P, Panzani RC.
Laboratoire d'immunologie, Universite de la Mediterranee, Hopital de Sainte Marguerite, Marseille, France. valerie.marin@ap-hm.fr
We have taken advantage of the temporary exposure of Marseilles population to castor bean seed proteins to follow 26 allergic patients more than 20 years after sensitization. Skin tests, specific immunoglobulin E (IgE) antibody assays, and specific immunoblots were performed. Skin test reactivity to Ricinus Communis and specific IgE concentrations decreased progressively and almost completely disappeared after 20 years. Specific IgE concentration displayed a fairly exponential decrease, with a half-life of 4.7 years. Thus, in the absence of any antigenic stimulation, directly by castor bean, or indirectly by cross-reactivity to other Euphorbiaceae, especially latex, IgE sensitization is bound to disappear.
PMID: 16754520 [PubMed - indexed for MEDLINE]
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