Effects of a synbiotic product on blood antioxidative activity in subjects colonized with H pylori

Lett Appl Microbiol. 2009 Jun;48(6):797-800. Epub 2009 Apr 1.

Effects of a synbiotic product on blood antioxidative activity in subjects colonized with Helicobacter pylori.

Hütt P, Andreson H, Kullisaar T, Vihalemm T, Unt E, Kals J, Kampus P, Zilmer M, Mikelsaar M. Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia. pirje.hutt@ut.ee

AIM: To evaluate the impact of the consumption of a synbiotic product on the antioxidative activity markers of blood in asymptomatic H. pylori-colonized persons.

METHODS AND RESULTS: Fifty-three healthy adult volunteers without gastric symptoms participated in a randomized, double-blind placebo-controlled study. The crossover consumption of the enterocoated capsules containing antioxidative Lactobacillusfermentum ME-3, Lact. paracasei 8700:2 and Bifidobacterium longum 46 with Raftilose P95 lasted for 3 weeks and did not change the H. pylori colonization. In H. pylori-positive subjects the sera values of total antioxidative status (TAS) were significantly lower compared to H. pylori-negative subjects (0.97 vs 1.05 mmol l(-1), P = 0.008). After the consumption of the synbiotic, TAS values (0.97 vs 1.03 mmol l(-1), P = 0.004) increased, while the ratio between oxidized and reduced glutathione (0.035 vs 0.030, P = 0.016) decreased in H. pylori-positive subjects.

CONCLUSIONS: The consumption of a synbiotic containing an antioxidative probiotic strain improved the reduced systemic antioxidative activity in H. pylori-colonized asymptomatic subjects.

SIGNIFICANCE AND IMPACT OF THE STUDY: A synbiotic product containing an antioxidative probiotic strain may be useful in the reduction of systemic oxidative stress in H. pylori infection.

PMID: 19344357 [PubMed - indexed for MEDLINE]

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