Neuro Endocrinol Lett. 2007 Dec 6;28(6) [Epub ahead of print]

Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome.

Maes M, Coucke F, Leunis JC. MCare4U Outpatient Clinics, Belgium. crc.mh@telenet.be.

There is now evidence that chronic fatigue syndrome (CFS) is accompanied by an increased translocation of endotoxins from gram-negative enterobacteria through the gut wall, as demonstrated by increased prevalences and median values for serum IgM and IgA against the endotoxins of gram-negative enterobacteria. This condition can also be described as increased gut permeability or leaky gut and indicates intestinal mucosal dysfunction (IMD). Here we report a case of a 13 year old girl with CFS who showed very high values for serum IgM against the LPS of some enterobacteria and signs of oxidative and nitrosative stress, activation of the inflammatory response system, and IgG3 subclass deficiency. Upon treatment with specific antioxidants and a "leaky gut diet", which both aim to treat increased gut permeability, and immunoglobins intravenously, the increased translocation of the LPS of gram negative enterobacteria normalized and this normalization was accompanied by a complete remission of the CFS symptoms.

PMID: 18063928 [PubMed - as supplied by publisher]

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written by Chronic fatigue, April 02, 2009

i have chronic fatigue and very bad guts problems, does this mean if i go on a leaky gut diet ill feel less tired and able to function again im fed up with no doing anything.

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written by Maff, April 02, 2009

Hi,

I am in the same boat as you with CFS and gut problems. I have learnt from experience and leaky gut (intestinal permeability) tests that when I have less gut symptoms I feel better in general.

So far there haven't been studies where a large number of CFS patients have been put on treatment for leaky gut to see if it helped their CFS in general but such studies are now underway. Many doctors and other healthcare professionals specializing in CFS have found that diagnosing and treating leaky gut helps a large number of their patients.

I would certainly recommend you get tested (a simple urine test) or just try diet and supplement recommendations for leaky gut and see if it helps.

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