| Somatic comorbidities in irritable bowel syndrome: fibromyalgia and chronic fatigue syndrome |
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Gastroenterol Clin Biol. 2009 Feb;33 Suppl 1:S17-25.
Somatic comorbidities in irritable bowel syndrome: fibromyalgia, chronic fatigue syndrome, and interstitial cystitis
Mathieu N. Clinique Universitaire d'Hépato-Gastroentérologie, Pôle DIGIDUNE, Centre Hospitalo-universitaire de Grenoble, France. NMathieu@chu-grenoble.fr
Fibromyalgia, chronic fatigue syndrome, and interstitial cystitis frequently overlap with irritable bowel syndrome (IBS). There is a positive correlation between the incidence of these comorbidities and increased health care seeking, reduction in quality of life, and higher levels of mood disorders, which raises the question of a common underlying pathophysiology. A possible central hypersensitization disorder seems to be particularly involved in the dysfunction of bidirectional neural pathways and viscerovisceral cross-interactions within the CNS, thus explaining these many extraintestinal manifestations in IBS.
PMID: 19303534 [PubMed - in process]
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| Last Updated on Monday, 09 November 2009 13:10 |
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