Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects

J Anim Sci. 2008 Sep 12. [Epub ahead of print]

Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects.

Lambert GP. Department of Exercise Science, Creighton University, Omaha, NE 68178.

The intestinal barrier is formed by enterocyte membranes, tight junctions, secreted mucus, and immunologic factors, such as tissue macrophages. Dysfunction of this barrier can be caused by different types of stress (e.g., physiological, pathological, psychological, pharmacological) and can lead to increased intestinal permeability. Increased permeability to endotoxin, a component of the walls of Gram-negative bacteria, causes local and(or) systemic inflammatory reactions. The immune response(s) can then promote more serious conditions. Exertional heat stroke is an example of such a condition. During severe exercise-heat stress, possibly combined with other stresses, reductions in intestinal blood flow and(or) direct thermal damage to the intestinal mucosa can cause intestinal barrier disruption and endotoxemia. The resulting inflammatory response is believed to be involved in altered thermoregulation and multiple-organ dysfunction. Possible means for preventing and(or) attenuating many stress-induced intestinal barrier problems include environmental, pharmaceutical, and(or) nutritional approaches.

PMID: 18791134 [PubMed - as supplied by publisher]

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