Supporting The Methylation Cycle Supporting The Methylation Cycle

What were the benifits of having the methylation cycle testing?

Discussion started by 3clicks 8 years ago

It was suggested to me by my ND that I might do the methylation cycle testing.  I have yet to hear how others have benefited from this testing, and where the testing was done.  Were the dietary changes, or whatever suggested worth the cost of the test?  It was suggested to me to do this with Dr. Amy Yasko in Calif.  I am very interested to hear of other people's experiences with this.

 

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Maff
Maff
It's a little confusing Tracy. MTHFR is an enzyme that produces the methylated form of folate (5-MTHF) as part of the methylation cycle. There are a number of genes that influence the activity of the enzyme and these also take the same name - MTHFR. They are distunguished by designations such as C677T which refer to the slight variations from the "normal" in the bases that make up their DNA.

You are absolutely right that these genes are inherited and would explain a family predisposition to poor methylation and everything that goes along with it e.g. psychological disorders, poor detoxification, high homocysteine etc. If you have SNPs for MTHFR and also folate deficiency due to stress, illness, poor diet, or gut dysbiosis...then you are in big trouble. Unfortunately I fall into that category as I'm sure many people with CFS and other environmental illnesses do!

Thanks for reading my essay - glad it made sense of what you had already figured out

Don't worry it's not you with the group emails. You should receive emails when somebody replies to a discussion you are actively involved in and also when a new discussion topic is started. You won't receive emails for new posts in discussions you have not replied to yourself - currently no way to change that unfortunately.
8 years ago
Tracy Mac
Tracy Mac
As I understand it MTHFR is genetic caused by a faulty gene? That would explain the prevalence in your family. Throw in a few triggers like anti-biotics and you are in trouble. I just read your thesis by the way. You described scientifically what I discovered experientially and experimentally! Weird.

How do I subscribe to these group discussions. I am a member but I'm not getting the updates. It must be my ADHD but I can't find the bit to click.
8 years ago
Maff
Maff
Hi,

If you have the chance to see Dr. Amy Yasko I would recommend in a heartbeat that you do. She is the leader in this field for sure. Her book helped me enourmously in understanding my own methylation SNP testing results and the best forms of supplements to address particularly issues within the cycle and adjoining biochemical pathways.

Under-methylation can be involved in environmental illnesses on so many important levels (not least neurotransmitter imbalances and poor detoxification capacity) that it is simply something we should all consider.

My own testing (images in group photos) revealed I have serious deficits in key methylation genes/enzymes...MTHFR, MTRR and COMT. I am homozygous for the poorly functioning variants in all of these...which fits very well with my symptoms of susceptibility to mood and cognitive dysfunction and poor detoxification. I now know however which specific forms of nutrients (particularly folate) that I require to bypass these problem areas.

I'm sure you've already done some research but take a look at the articles I posted in a group bulletin to learn more about the importance of the methylation cycle in health and disease.
8 years ago

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