Acetaldehyde poisoning and the cognitive and mood symptoms of Candida
An article from MCS America this week included the Material Safety Data Sheet (MSDS) for acetaldehyde and I thought some of the information contained would be of interest to those affected by Candida-related illness/intestinal yeast overgrowth and who suffer from depression, anxiety, mood swings, irritability, restlessless...and the rest. Here are a few key quotes from the MSDS:
"It [acetaldehyde] may affect behavior/central nervous system and cause central nervous system depression."
"Symptoms of chronic acetaldehyde exposure may resemble those of chronic alcoholism. Acetaldehyde is the a metabolite of ethanol in humans and has been implicated as the active agent damaging the liver in ethanol-induced liver disease."
Now I know that Candida/yeast-derived chronic acetaldehyde poisoning has caused significant damage and/or dysfunction to both my central nervous system and liver...but finding a doctor who will acknowledge this and not stop working with me until a solution is found has so far proved impossible - even if I could afford the fees. Hard to work when chronically poisoned by a toxin like acealdehyde!
Anyway, this article provides a few tips on how to mitigate the toxic effects of acetaldehyde using specific nutrients, namely pantethine (bioactive vitamin B5) and molybdenum (trace mineral): The Candida/Aldehyde Detox Pathway and the Molybdenum Connection
N.B. Candida/yeast ferment carbohydrates to form ethanol (drinking alcohol). This is converted by the body into acetaldehyde, an even more toxic chemical responsible for the symptoms of alcoholic hangovers, before eventually being broken down into non-toxic acetic acid. Overgrowth of Candida/yeast may lead to a build up of the highly toxic acetaldehyde as the body struggles to constantly detoxify it.
The problem is that there are other factors that determine our ability to detoxify alcohols and aldehydes. The alcohol and aldehyde dehydrogenase enzymes require the electron donor NAD which gets converted to NADH (I think this is correct if memory serves me). This can be problematic as NAD can get used up rapidly as it is also involved in ATP (energy) production in the Kreb's cycle and electron transport chain. Because of its reactivity you can't supplement NAD so molybdenum and panthethine are the best options at present.
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