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Chemical Induced Brain Dysfunction Shown in Multiple Chemical Sensitivities





MCS America

Lourdes Salvador's Column

...Co-founder of MCS America discusses the latest Multiple Chemical Sensitivity issues.









Lourdes Salvador volunteers as a writer and social advocate for the recognition of multiple chemical sensitivity (MCS). She was a passionate advocate for the homeless and worked with her local governor to provide services to the homeless through a new approach she created to end homelessness. That passion soon turned to advocacy and activism for people with MCS and the medical professionals who serve them. She co-founded MCS Awareness in 2005 and went on to found MCS America in 2006. She serves as a partner for Environmental Education Week, a partner for the Collaborative on Health and the Environment (CHE), and a supporter for the American Cancer Society: Campaign for Smokefree Air.


For more information visit MCS America




Monday, November 9th, 2009:


Chemical Induced Brain Dysfunction Shown in Multiple Chemical Sensitivities


by Lourdes Salvador



Some of the earliest research done on people with multiple chemicals sensitivity (MCS) involved brain images taken before, during, and after chemical exposure. 


These early studies consistently showed lower baseline blood flow to the brain which worsened during low-level chemical challenges, leading to the conclusion that chemical exposure caused neurocognitive impairment in this population.


Researchers in Spain repeated this procedure with chemical products at non-toxic concentrations and compared patients diagnosed with MCS to those without MCS. 


The MCS patients consistently showed reduced baseline blood flow to the brain, which worsened after the chemical challenge, again supporting the earlier findings. 


People with MCS experience neurological and other symptoms upon exposure to minute amounts of chemicals found in fragrances, pesticides, and other common chemicals.


Orriols and colleagues say these findings support the “poorer quality of life and neurocognitive function at baseline, and neurocognitive worsening after chemical exposure” experienced by people with MCS.


The method used for the brain scans is known as SPECT (Single Photon Emission Computerized Tomography) technology.  SPECT performs brain scans which record brain functioning by measuring perfusion (blood flow). 


Individuals with chronic symptoms show long-term reduced blood flow to the brain and reduced ability of the brain to take up a tracer substance in the early phase of injection, indicating a pattern of neurotoxic metabolic abnormality. 


Over 90% of MCS patients exhibit a pattern of neurotoxic metabolic abnormalities in the brain that is consistent with toxic encephalopathy, but that is not consistent with the changes associated with previously implicated psychiatric diseases. 


SPECT brain scans on MCS patients with chronic symptoms following toxic exposure to various petrochemical, perfume, and related compounds have provided researchers evidence to support an organic, biological basis to MCS when compared with healthy control subjects.


SPECT scans have uncovered blood flow alterations in patients with fibromyalgia, typically involving increased uptake of tracer substances, leading researchers to questions whether fibromyalgia may also be a toxicological disease of a different nature.


Chemicals appear to be capable of altering brain function in a significant way.  This alteration of brain function seems to be responsible for the many neurocognitive effects of MCS.




Orriols R, Costa R, Cuberas G, Jacas C, Castell J, Sunyer J.  Brain dysfunction in multiple chemical sensitivity.  J Neurol Sci. 2009 Oct 2.




For more articles on this topic, see: MCSA News.


Copyrighted 2009 Lourdes Salvador & MCS America



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