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Silver Nanoparticles Linked to Genetic Mutations





MCS America

Lourdes Salvador's Column

...Co-founder of MCS America discusses the latest Multiple Chemical Sensitivity issues.









Lourdes Salvador is the founder of MCS America, a science writer, and a social advocate for the greater awareness of environmental contamination, human toxicology, and propagation of multiple chemical sensitivity (MCS) as a disorder of organic biological origin induced by toxic environmental insults.

For more information visit MCS America




Monday, June 11th, 2012:


Silver Nanoparticles Linked to Genetic Mutations

Health Impacts of Wood Smoke Devalues Real EstateHealth Impacts of Wood Smoke Devalues Real EstateHealth Impacts of Wood Smoke Devalues Real Estate

by Lourdes Salvador



Products with added silver nanoparticles are cropping up at an alarming pace. Manufacturers have jumped on the bandwagon to infuse silver nanoparticles in everything from clothing, first aid remedies, implants, and air fresheners to the enamel interior of washing machines.


Yet, scientists concerned about the potential health impacts warn that not enough testing has been done to determine the safety of silver nanoparticles. At the same time, these products are increasingly more difficult to avoid.


Mei and colleagues of the National Center for Toxicological Research, Jefferson, Arkansas have now discovered scientific evidence that silver nanoparticles increase oxidative stress and induce mutations in mouse lymphoma cells.


In the study, exposure to silver nanoparticles induced a dose-responsive increase in oxidative DNA damage. Gene expression analysis using an oxidative stress and antioxidant defense reaction showed that 17 of 59 genes were altered in the cells receiving silver nanoparticles.


“These genes are involved in production of reactive oxygen species, oxidative stress response, antioxidants, oxygen transporters, and DNA repair,” says Mei.


This is of interest to environmental medicine specialists, as oxidative stress has also been linked to multiple chemical sensitivity (MCS). Many of the signs and symptoms of MCS can be linked to “elevated levels of peroxynitrite or inflammatory cytokines, oxidative stress, elevated NMDA and TRPV1 receptor activity, ATP and BH4 depletion and others,“ according to researcher Marin Pall.


It is likely possible that other toxicants like silver nanoparticles have a similar effect on the human body. Thus far, treatments aimed at reversing oxidative stress and correcting the other imbalances have shown to be quite successful.



Mei N, Zhang Y, Chen Y, Guo X, Ding W, Ali SF, Biris AS, Rice P, Moore MM, Chen T. Silver nanoparticle-induced mutations and oxidative stress in mouse lymphoma cells. Environ Mol Mutagen. 2012 May 10. doi: 10.1002/em.21698. [Epub ahead of print]



For more articles on this topic, see: MCSA News.


Copyrighted 2012 Lourdes Salvador & MCS America



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