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Depression: Neurotransmitters, Methylation and Nutritional Therapy - References



Allocca JA (2007) Balancing Serotonin and Norepinephrine Levels: The Treatment of Choice

Almeida OP McCaul K Hankey GJ Norman P Jamrozik K Flicker L (2008) Homocysteine and depression in later life Archives of General Psychiatry 65(11):1286-94

Alpert JE Papakostas GI and Mischoulan D (2008) One-Carbon Metabolism and the Treatment of Depression: Roles of S-Adeonosyl-L-Methionine and Folate In: Mischoulan D (ed) (2008) Natural Medications for Psychiatric Disorders: Considering the Alternatives Lippincott Williams & Wilkins

Bear MF Connors BW and Paradiso MA (2001) Neuroscience: Exploring the Brain (2nd edition) Lippincott Williams & Wilkins

Belmaker RH and Agam G (2008) Major depressive disorder New England Journal of Medicine 358(1):55-68

Berlanga C Ortega-Soto HA Ontiveros M Senties H (1992) Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine Psychiatry Research 44(3):257-62

Birdsall TC (1998) 5-HydroxyL-tryptophan: A Clinically-Effective Serotonin Precursor Alternative Medicine Review 3(4)271:80

Bjelland I Tell GS Vollset SE Refsum H Ueland PM (2003) Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study Archives of General Psychiatry 60(6):618-26

Bottiglieri T Laundy M Crellin R Toone BK Carney MW Reynolds EH (2000) Homocysteine, folate, methylation, and monoamine metabolism in depression Journal of Neurology, Neurosurgery, and Psychiatry 69(2):228-32

Coppen A and Bailey J (2000) Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial Journal of Affective Disorders 60(2):121-30

Coppen A and Bolander-Gouaille C (2005) Treatment of depression: time to consider folic acid and vitamin B12 Journal of Psychopharmacology 19(1):59-65

Crellin R Bottiglieri T and Reynolds EH (1993) Folates and psychiatric disorders: clinical potential Drugs 45:623–36

Dailly E Chenu F Renard CE Bourin M (2004) Dopamine, depression and antidepressants Fundamental and Clinical Pharmacology 18(6):601-7

Dantzer R O'Connor JC Freund GG Johnson RW Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain Nature Reviews Neuroscience 9(1):46-56

De Vanna and Rigamonti R (1992) Oral S-adenosylmethionine in depression Current Therapeutic Research 52:478-85

Evers EAT van der Veen FM Jolles J Deutz NEP, Schmitt JAJ (2009) The effect of acute L-tryptophan depletion on performance and the BOLD response during a Stroop task in healthy first-degree relatives of patients with unipolar depression Psychiatry Research 173(1):52-8

Fava M Rosenbaum JF MacLaughlin R Falk WE Pollack MH Cohen LS Jones L Pill L (1990) Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative antidepressant Journal of Psychiatric Research 24(2):177-84

Fava M Rosenbaum JF Birnbaum R Kelly K Otto MW MacLaughlin R (1992) The thyrotropin response to thyrotropin-releasing hormone as a predictor of response to treatment in depressed outpatients Acta Psyciatrica Scandinavica 86(1):42-5

Fernstrom JD and Fernstrom MH (2007) L-tyrosine, phenylalanine, and catecholamine synthesis and function in the brain Journal of Nutrition 137:1539S-1547S

Folstein M Liu T Peter I Buell J Arsenault L Scott T Qiu WW (2007) The homocysteine hypothesis of depression American Journal of Psychiatry 164(6):861-7

Fournier JC DeRubeis RJ Hollon SD Dimidjian S Amsterdam JD Shelton RC Fawcett J (2010) Antidepressant drug effects and depression severity: a patient-level meta-analysis Journal of the American Medical Association 303(1):47-53

Garcion E Wion-Barbot N Montero-Menei CN Berger F Wion D (2002) New clues about vitamin D functions in the nervous system Trends in Endocrinology and Metabolism 13(3):100-5

Gardner A and Boles RG (2008) Mitochondrial Energy Depletion in Depression with Somatization Psychotherapy and Psychosomatics 77:127-129

Gariballa S and Forster S (2007) Effects of dietary supplements on depressive symptoms in older patients: a randomised double-blind placebo-controlled trial Clinical Nutrition 26(5):545-51

Gelenberg AJ Wojcik JD Growdon JH Sved AF Wurtman RJ (1980) L-tyrosine for the treatment of depression American Journal of Psychiatry 137(5):622-3

Gelenberg AJ Wojcik JD Falk WE Baldessarini RJ Zeisel SH Schoenfeld D Mok GS (1990) L-tyrosine for depression: a double-blind trial Journal of Affective Disorders 19(2):125-32

Gilbody S Lightfoot T and Sheldon T (2007) Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity Journal of Epidemiology and Community Health 61(7):631-7

Grevet EH Tietzmann MR Shansis FM Hastenpflugl C Santana LC Forster L Kapczinskil F Izquierdo I (2002) Behavioural effects of acute phenylalanine and L-tyrosine depletion in healthy male volunteers Journal of Psychopharmacology 16(1):51-5

Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials British Medical Journal 316(7135):894-8

Honoré P Møller SE and Jørgensen A (1982) Lithium + L-tryptophan compared with amitriptyline in endogenous depression Journal of Affective Disorders 4(1):79-82

Institute for Functional Medicine (2005) Textbook of Functional Medicine Institute for Functional Medicine

Janicak PG Lipinski J Davis JM Altman E Sharma RP (1989) Parenteral S-adenosyl-methionine (SAMe) in depression: literature review and preliminary data Psychopharmacology Bulletin 25(2):238-42

Kagan BL Sultzer DL Rosenlicht N Gerner RH (1990) Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial American Journal of Psychiatry 147:591-95

Kamphuis MH Geerlings MI Grobbee DE Kromhout D (2008) Dietary intake of B6-9-12 vitamins, serum homocysteine levels and their association with depressive symptoms: the Zutphen Elderly Study European Journal of Clinical Nutrition 62:939-45

Kim JM Stewart R Kim SW Yang SJ Shin IS Yoon JS (2008) Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression British Journal of Psychiatry 192(4):268-74

Kirsch I Deacon BJ Huedo-Medina TB Scoboria A Moore TJ Johnson BT (2008) Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration PLoS Medicine 5(2):e45

Lake J (2006) Textbook of Integrative Mental Health Care Thieme

Licinio J and Wong M (eds) (2005) Biology of Depression: From Novel Insights to Therapeutic Strategies Wiley-VCH

Lin YT Lin MH Lai HY Chen LK Hwang SJ Lan CF (2009) Regular vitamin B12 supplementation among older Chinese men in a veterans care home in Taiwan Archives of Gerontology and Geriatrics 49(1):186-9

Lythe KE Anderson IM Deakin JF Elliott R Strickland PL (2005) Lack of behavioural effects after acute L-tyrosine depletion in healthy volunteers Journal of Psychopharmacology 19(1):5-11

McAulay V Deary IJ Ferguson SC Frier BM (2001) Acute hypoglycemia in humans causes attentional dysfunction while nonverbal intelligence is preserved Diabetes Care 24(10):1745-50

McLean A Rubinsztein JS Robbins TW Sahakian BJ (2004) The effects of L-tyrosine depletion in normal healthy volunteers: implications for unipolar depression Psychopharmacology 171(3):286-97

McTavish SF Mannie ZN Harmer CJ Cowen PJ (2005) Lack of effect of L-tyrosine depletion on mood in recovered depressed women Neuropsychopharmacology 30(4):786-91

Mischoulon D and Raab MF (2007) The role of folate in depression and dementia Journal of Clinical Psychiatry 68(Suppl 10):28-33

Moreno FA Parkinson D Palmer C Castro WL Misiaszek J El Khoury A Mathé AA Wright R Delgado PL (2010) CSF neurochemicals during L-tryptophan depletion in individuals with remitted depression and healthy controls European Neuropsychopharmacology 20(1):18-24

Morris DW Trivedi MH and Rush AJ (2008) Folate and unipolar depression Journal of Alternative and Complementary Medicine 14(3):277-85

Ng TP Feng L Niti M Kua EH Yap KB (2009) Folate, vitamin B12, homocysteine, and depressive symptoms in a population sample of older Chinese adults Journal of the American Geriatrics Society 57(5):871-6

Pariante CM and Lightman SL (2008) The HPA axis in major depression: classical theories and new developments Trends in Neurosciences 31(9):464-8

Passeri M Cucinotta D Abate G Senin U Ventura A Stramba Badiale M Diana R La Greca P Le Grazie C (1993) Oral 5'-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study Aging 5(1):63-71

Poldinger W Calanchini B and Schwarz WA (1991) Functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxyL-tryptophan and fluvoxamine Psychopathology 24:53-81.

Reynolds EH Carney MW and Toone BK (1984) Methylation and mood Lancet 2(8396):196-8

Roiser JP McLean A Ogilvie AD Blackwell AD Bamber DJ Goodyer I Jones PB Sahakian BJ (2005) The subjective and cognitive effects of acute phenylalanine and L-tyrosine depletion in patients recovered from depression Neuropsychopharmacology 30(4):775-85

Rosenbaum JF Fava M Falk WE Pollack MH Cohen LS Cohen BM Zubenko GS (1988) An open-label pilot study of oral S-adenosyl-L-methionine in major depression: interim results Psychopharmacology Bulletin 24(1):189-94

Rosenbaum JF Fava M Falk WE Pollack MH Cohen LS Cohen BM Zubenko GS (1990) The antidepressant potential of oral S-adenosyl-l-methionine Acta psychiatrica Scandinavica 81(5):432-6

Ryan-Harshman M and Aldoori W (2008) Vitamin B12 and health Canadian Family Physician 54(4):536-41

Sánchez-Villegas A Doreste J Schlatter J Pla J Bes-Rastrollo M Martínez-González MA (2009) Association between folate, vitamin B(6) and vitamin B(12) intake and depression in the SUN cohort study Journal of Human Nutrition and Dietetics 22(2):122-33

Shaw K Turner J and Del Mar C (2002) L-tryptophan and 5-hydroxyL-tryptophan for depression Cochrane Database of Systematic Reviews (1):CD003198

Skarupski KA Tangney C Li H Ouyang B Evans DA Morris MC (2010) Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time American Journal of Clinical Nutrition doi:10.3945

Spring B Hitsman B Pingitore R McChargue DE Gunnarsdottir D Corsica J Pergadia M Doran N Crayton JW Baruah S Hedeker D (2007) Effect of L-tryptophan depletion on smokers and nonsmokers with and without history of major depression Biological Psychiatry 61(1):70-7

Stargrove MB Treasure J and McKee DL (2008) Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies Elsevier Health Sciences

Stewart JC Rand KL Muldoon MF Kamarck TW (2009) A prospective evaluation of the directionality of the depression-inflammation relationship Brain, Behavior, and Immunity 23(7):936-44

Strachan MW Deary IJ Ewing FM Frier BM (2000) Recovery of cognitive function and mood after severe hypoglycemia in adults with insulin-treated diabetes Diabetes Care 23(3):305-12

Taylor MJ Carney S Geddes J Goodwin G (2003) Folate for depressive disorders Cochrane Database of Systematic Reviews (2):CD003390

Thomson F and Craighead M (2008) Innovative approaches for the treatment of depression: targeting the HPA axis Neurochemical Research 33(4):691-707

Thomson J Rankin H Ashcroft GW Yates CM McQueen JK Cummings SW (1982) The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo Psychological Medicine 12(4):741-51

Tortora GJ and Derrickson BH (2009) Principles of Anatomy and Physiology (12th edition) Wiley

van Praag HM (1979) Central serotonin: Its relation to depression vulnerability and depression prophylaxis In: Obiols J Ballus C Gonzalez Monclus
E  Pujol J (eds) Biological Psychiatry Today Elsevier

Voracek M and Tran US (2007) Dietary L-tryptophan intake and suicide rate in industrialized nations Journal of Affective Disorders 98(3):259-62

Whitney EN Cataldo CB and Rolfes SR (2002) Understanding Normal and Clinical Nutrition (6th edition) Wadsworth

World Health Organization (2010) Depression (online) last accessed 15.06.10 at

Wurtman RJ Wurtman JJ Regan MM McDermott JM Tsay RH Breu JJ (2003) Effects of normal meals rich in carbohydrates or proteins on plasma L-tryptophan and L-tyrosine ratios American Journal of Clinical Nutrition 77(1):128-32




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