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Stimulation - The bad kind

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Well, I’ve had a couple of rough ‘wired’ days which aren’t hugely enjoyable.

The best way to describe the feeling is to imagine not having slept for 2 days, then using red bull or coffee to keep you awake. You don’t feel tired enough to sleep yet you are really physically and mentally shattered.

The difference with me is that I often get this feeling with certain supplements, for which there is not obvious rational medical explanation for.

The latest supplement to affect me in this way is L-glutamine, which is highly unfortunate as there are many benefits to taking this non essential amino acid.

L-Glutamine is helpful for:

- blood sugar balance
- food cravings
- gastrointestinal function
- muscle growth and recovery

And users range from people with chronic illness (moi) to professional body builders.

The therapeutic dosage is between 1-20g a day with no known significant side effects. It can be taken as capsules or in powder form mixed with water, and is surprisingly pleasant tasting considering there are no other ingredients or fillers.

I experimented at the top end of those dosage guidelines without favourable results. As such I’m going to give my body at least a few days to reset with a view to adding this in at a much lower dose.

Generally feeling positive all things considered. When thinks aren’t quite going your way and you’ve had a setback it’s all too easy to fall into a complete decline which means you stray from your program and diet. I was a prime candidate for this happening, especially when I put a lot of effort and positive energy into making changes and I had a setback.

Balance is the key and aiming to get back on the horse as soon as possible once you slip up will only help you in the long run.


Stimulation - The bad kindDynamic Neural Retraining Program (DNRS)


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  • I know the 'wired' feeling well, as I'm sure many other readers do. It IS strange you get this stimulation from glutamine but there is one mechanism I know of that could explain it.

    Glutamine is converted to and from gluamic acid/glutamate in the body, as needed. It just so happens that glutamate is the major excitatory neurotransmitter in the brain and central nervous system (CNS). I believe there are a number of reasosn why the glutamine/glutamate balance would shift towards glutamate but the only one I can think of right now is ammonia detoxification.

    Like you say, you need to experiment to find the right dose for you....there are bound to be setbacks along the way.

    I get the same wired feelings and problems you describe but only with substances known to have a stimulant action - no matter how weak or how little I take e.g. ginseng, SAMe, l-tyrosine, acetyl-l-carnitine, d-ribose...

    Keep getting on that horse and keep blogging!

    Comment last edited on about 8 years ago by Maff

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