EiR Blog

Last week I blogged about how the two phases of liver detoxification can get out of balance due to chronic exposure to toxins, for example, and how this can impact on a person's health. As discussed, the most common problem is that phase 1 speeds up and phase 2 cannot keep up - someone in this situation is known as a pathological detoxifier because of their increased risk for symptoms and disease. The previous blogs with more detailed information can be found at: Pathological Detoxifiers and Environmental Illness Detoxification Profile Results - The Pathological Detoxifier and Chronic Illness   Now I want to take a look at foods and supplements that pathological detoxifiers can use to balance their liver detoxification pathways and improve their health. Essentially what we want to do is slow down phase 1 while speeding up phase 2. There are many foods and supplements that can help. One...

  A little while ago a member posted in the forums about a subject which hasn't been addressed specifically on the site before - 'pathological detoxifiers'. I thought this subject deserved more attention as it can be a vital piece in the puzzle for those suffering from environmental illnesses including multiple chemical sensitivity (MCS), chronic fatigue syndrome (ME/CFS), and Gulf War syndrome. To define what it means to be a pathological detoxifier first we need to understand the basics of how liver detoxification works:   Liver Detoxification The detoxification of toxins by the liver basically occurs in two phases. Substances the liver must detoxify can be exogenous (from outside of the body) such as alcohol, drugs, pollutants, or endogenous (from inside the body) such as hormones. Most toxins are fat-soluble which means they are easily absorbed and stored in the body (particularly fatty tissues, including the brain), but are difficult to...

Following on from my blog - Pathological Detoxifiers and Environmental Illness which explained the process of detoxification in the liver and when someone might be termed a 'pathologicial detoxifier' - I wanted to share the results of my own Detoxification Profile and explain how the results related to my illness at the time and subsequent developments. The Detoxification Profile uses caffeine, paracetamol, and aspirin, to determine how well phase1 and some of the most important phase 2 liver detoxification pathways are functioning.   My Detoxification Profile Results     Interpretation As you can see, although my phase 1 is within the reference range, it is towards the upper end of normal. In combination with this my phase 2 glutathione conjugation is borderline low. The other phase 2 pathways are all what Genova ,I believe, now classes as high and indicates increased toxic exposure.  Other testing revealed my d-glucaric acid was high...