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Treating Cognitive Dysfunction (Brain Fog) in CFS & Fibromyalgia





Dr. Jacob Teitelbaum

Dr. Jacob Teitelbaum's Column advice on CFS, Fibromyalgia and other Health Topics.











Jacob Teitelbaum MD is Medical Director of the Fibromyalgia and Fatigue Centers
( ). Senior author of the landmark studies "Effective Treatment of Chronic Fatigue Syndrome and Fibromyalgia -- a Placebo-controlled Study" & “Effective Treatment of CFS & Fibromyalgia with D-Ribose”. Author of the best-selling book” From Fatigued to Fantastic!”(3rd ed-Penguin/Avery Oct 4, 2007) , " Three Steps to Happiness! Healing through Joy", and “Pain Free 1-2-3- A Proven Program to Get YOU Pain Free! “(McGraw Hill, 2006). He does numerous media appearances, including CNN and FOX National News and is a frequent guest on Oprah and Friends with Dr. Oz.. He lives in Kona, Hawaii. Visit his web site at



You can benefit from Dr. Teitelbaum's wisdom and experience by visiting us at The Environmental Illness Resource regularly to read articles from his latest newsletter!




Monday, September 1st, 2008:


Treating Cognitive Dysfunction ("Brain Fog") in CFS & Fibromyalgia


by Jacob Teitelbaum MD



Brain fog is very common in CFS/FMS, and presents as:


1. Horrible short term memory,

2. Difficulty with word finding and word substitution (e.g., substituting the word "fork" for "knife," or your neighbor's name for your husband's name—not a Freudian slip in CFS), and

3. Approximately 30% of those with CFS/FMS have episodic disorientation lasting ~ 30-60 seconds. This often occurs when driving or even turning down a supermarket aisle. It can feel scary, but is not dangerous. Though you may not know where you are (or are going) people seem able to drive or walk safely till it passes. This can also manifest as briefly not recognizing common objects or names (even of children).

Brain fog can sometimes be the scariest part of the illness for some—especially professionals that had been functioning at a very high level. Though standard testing will often not pick up the problem (nor is it designed to), in some cases the brain fog makes it hard or even impossible to continue one's job. In other cases, brain fog can be mild.


The good news is that brain fog tends to resolve with treatment along with the pain and fatigue. In this week's feature article, we will discuss the key treatments that can help you to get your brain back!



Where do I start?


Poor energy production in the brain, with associated alterations in blood flow (e.g., to the sides of the brain where the speech centers are) as well as alterations in neurotransmitters (brain chemicals like serotonin, dopamine, adrenaline or acetylcholine), blood pressure, or blood sugar can all contribute to your brain fog. Because of this, the overall "SHINE Protocol" is very helpful for brain fog as well as CFS/FMS. Let's look at the key issues and treatments.


1. Sleep - Getting your 8 hours of sleep a night is critical, but make sure your sleep, pain or other medications are NOT the cause of your feeling foggy the next day. Add natural treatments at bedtime like melatonin (1/2-1 mg), calcium and magnesium, and the Revitalizing Sleep Formula. These are less likely to cause brain fog and will lower the amount of medications needed. Work with your doctor to leave off 1 of your sleep medications each night as well, to see if any of them are leaving you hung over/foggy the next day. If so, play with the medications and doses to find a mix that works with less next day sedation. Using a low dose of several sleep (or pain) medications is more effective and has fewer side effects than a high dose of 1 or 2 medications. For more information on how to get a good night's sleep, see Sleep and Insomnia. Explore the role, also, of any other medications which may be sedating.

2. Optimize Thyroid function by adjusting the thyroid type and dose based on your symptoms, using only the Free T4 blood test to make sure you are staying in the normal range for safety. Do not let your doctor use the TSH test to monitor treatment in CFS/FMS. It is not reliable in this illness and you will be undertreated and brain foggy. Some people do better taking part (or all) of their thyroid dose at bedtime. For more on treating thyroid problems, see Thyroid Hormone Deficiency—An Overview.

3. In men, optimize testosterone; and in women, estrogen and progesterone. If you get irritable when hungry, optimize adrenal support, as recurrent low blood sugar also can trigger brain fog.

4. If you have nasal congestion or sinusitis or irritable bowel syndrome (gas, bloating, diarrhea or constipation) you likely have Candida/yeast overgrowth, and this can leave you VERY foggy. This is discussed in my book, From Fatigued to Fantastic! (and I will do a newsletter article on Candida soon), but the key is to take the medication Diflucan 200 mg a day for 6-12 weeks while avoiding sugar and taking Acidophilus Pearls and Anti-Yeast herbals.

5. Optimize nutritional support with the Energy Revitalization System and Ribose (Corvalen). Ask your physician if you can have a series of B12 shots (1,000-5,000 mcg of the hydroxycobalmin form of B12 each few days for a total of 15 doses, then as needed). People can often learn to give their own B12 shots. At the Fibromyalgia and Fatigue Centers we use special "Energy Injections" that are very helpful. If you have dry eyes, dry mouth or depression, add 1 teaspoon of fish oil a day or 3-4 servings of tuna or salmon each week.

6. Stay hydrated. If your mouth or lips are dry, you're dehydrated. It's amazing how the mind can clear a lot sometimes after simply drinking a glass of cool water. Getting fresh air and sunshine (in moderation—don't burn) can also help.

7. So called "Energy Drinks" loaded with caffeine and sugar are loan sharks—avoid them. Instead, drink 1-2 cups of tea (made from real tea bags or leaves—not the powdered/bottled stuff loaded with sugar). This is often enough to jump start your brain in a healthy way without crashing you later, and the antioxidants in 1-2 cups of tea a day help your CFS and overall health as well. Avoid the caffeine after 2 pm so it won't disrupt sleep.



Treatments for Symptom Relief


While you are instituting the treatments above (and if your physician is not familiar with the illness, see a Fibromyalgia and Fatigue Center physician who knows how to help you), here are a few treatments that can offer symptomatic relief:


1. Dexedrine or Ritalin - Though these amphetamine family medications are markedly overused in hyperactive kids, they are UNDERUSED in CFS. These medications actually can help restore balance in CFS/FMS by raising dopamine levels and brain wave frequency to normal, stabilizing low blood pressure and autonomic dysfunction and decreasing the tendency to sleep apnea by causing weight loss. Most adults find 5-12.5 mg each morning to be optimal. Younger patients (under 22 years old) often find they need higher doses (I generally do not prescribe over 30 mg a day), though the reason for this is not clear. I suspect, though, that it is because younger patients have more autonomic dysfunction.

2. Remember - This nutrient and herbal mix can be very helpful for brain fog, and is worth using first, but frankly the Dexedrine is more effective for brain fog. It is worth trying though and can even be combined with the Dexedrine for optimal effect. Take 2 capsules a day, which contains (per 2 capsules):

Vitamin B6 (as pyridoxine HCl) - 15 mg
Folic Acid - 800 mcg
Vitamin B12 (as cyanocobalamin) - 500 mcg
Alpha Lipoic Acid - 600 mg
Bacopa (Bacopa monnieri); Aerial Part Extract standardized to contain 20% bacosides - 300 mg
Ginkgo (Ginkgo biloba) Leaf Extract; standardized to contain 24% ginkgoflavonglycosides, 6% terpene lactones, and 2% bilobalide - 120 mg


Give all of the above treatments 6 weeks to fully kick in. Even though some of these help within days, natural treatments often take 6 weeks to heal the systems involved so you can feel better.


Like fibromyalgia pain, brain fog responds well to treatment. The problem is largely that most physicians are simply not trained in these illnesses. Most of these treatments can be done on your own, and you can ask your physician to assist with those requiring a prescription. If they refuse, get a consultation with a Fibromyalgia and Fatigue Center (FFC) physician. In addition, though usually not as well trained in CFS/FMS as the FFC doctors, Holistic physicians are often familiar with these treatments as well.


You can get back both your life—and your mind!




Dr. T






Used with permission from Dr Jacob Teitelbaum's free newsletters-available at



Learn more from Dr. Teitelbaum's books:



From Fatigued To Fantastic


From Fatigued to Fantastic!: A Proven Program to Regain Vibrant Health, Based on a New Scientific Study Showing Effective Treatment for Chronic Fatigue and Fibromyalgia

Buy from

Buy From Cognitive Dysfunction (Brain Fog) in CFS & Fibromyalgia

Pain Free 1-2-3


Pain Free 1-2-3: A Proven Program for Eliminating Chronic Pain Now!

Buy from

Buy From Cognitive Dysfunction (Brain Fog) in CFS & Fibromyalgia








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People in this conversation

  • Hi Michael, sorry to hear of your serious health problems. Did you have any major toxic exposures during active service and/or deployment? This could certainly have contributed to your hypopituitarism but perhaps your doctor has found another cause? In any case the usual treatment of this condition would be with hormone replacement. Testosterone patches are now available that release a steady supply to make up for what your body is not producing itself. The pituitary gland produces hormones that stimulate the release of other hormones throughout the endocrine system such as adrenal and thyroid hormones which are essential to health. Have you had levels of thyroid hormones and cortisol checked? Replacement testosterone alone should help with your fatigue but addressing adrenal and thyroid hormone deficiencies will make a huge difference as well.
    Lisdexamfetamine may help in the short-term but such stimulants tend to deplete the body and in the long-term result in more pronounced fatigue and exhaustion. I would advise you to discuss testosterone replacement and testing of other hormone levels (particularly adrenal and thyroid hormones) with your doctor.
    All the best!

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