Best way to raise glutathione ?

Hi all,
I read about Matt using tribulus and was intrigued by that.

I found this which shows pycnogenol raised glutathione significantly within 1 monht
www.ncbi.nlm.nih.gov/pubmed/16984739

Sounds wonderful ! So, I'm going to try that as I couldn't find anything similar for Tribulus.

I also take : 250 mg vitamin C 2x / day, 400 alpha-tocopherol vitamin E, 125 mg mixed tocotrienols and soon turmeric and pycnogenol for antioxidants

My questions are: do you think the above has a goodchance of raising my glutathione ?

Also Matt , you said the Tribulus got ridof the pale poop situation. Was that because it raised glutathione ? I have the same issue right now and I eat a LOT of fat so this is a problem.

Mer

Hi Mersan,

Welcome to the forums

It looks like you've done your research - I think us EI sufferers use PubMed more than doctors!

All of the supplements are taking are important for regenerating glutathione. Converting it back from its oxidised form to its reduced form (the form that can act as an antioxidant). So yes, certainly keep taking those, they should certainly help raise your reduced glutathione levels if you get good quality supplements that are well absorbed. You might want to up your vitamin C a bit. Perhaps 500mg 3x/day. It doesn't last long in the body so regular taking it throughout the day is important. 1500mg per day is certainly safe.

There are lots of studies showing that Tribulus terrestris raises glutathione although admittedly most are animal studies at this stage. Here are a handful I found for you:

http://www.apocp.org/cancer_download/Volume7_No2/Manish%20Kumar.pdf

http://www3.interscience.wiley.com/journal/118570415/abstract?CRETRY=1&SRETRY=0

http://www.msptm.org/files/45_-_51_Jagadeesan_G.pdf

http://www.doaj.org/doaj?func=abstract&id=315918

http://www.informahealthcare.com/doi/abs/10.1080/13880200701538872


The reason Tribulus produces a healthier stool colour is because it improves the flow of bile and it is bile pigments that give stools their dark brown colour once they are acted upon by bacteria in the gut. If you eat a lot of fat you really need to have good bile flow to digest it. Tribulus and other bile enhancing herbs can help a lot here as can digestive enzyme supplements containing lipase.<br /><br />Post edited by: Maff, at: 2009/09/23 17:49

Thanks Matt. I will order some lipase.
Have you been able to find plain lipase ?

If the current anitoxidandts plus pycnogenol and turmeric don't help with bile flow I'll try the tribulus

I was wondering ifthe tribulus also helped you with fatigue ?

No problem

I'm not aware of a supplement that contains lipase alone I'm afraid; it tends to come in digestive enzyme formulas only.

Yes Tribulus has also helped my fatigue but this is almost certainly due to it improving my ability to handle stress. It seems to work as a tonic for improving overall well-being and stress tolerance.

Good luck with the pycnogenol and turmeric, they have proven benefits so should help somewhat.

www.nleducation.co.uk/resources/reviews/...to-iv-therapy/#_ftn6

haven't tried it but Acetylglutathione is supposed to be absorbed well,
also undenatured whey protein my be worth looking in to, Cheney said it was giving amazing results to his patients then he back tracked a little?

www.prohealth.com/library/showarticle.cfm?libid=8874

good luck!

Thanks for that information CaptainInsano - I have to admit I had not come across the use of the acetyl form of glutathione before but I've just done a little research and it sounds promising. In one study I came across the authors compared a regular glutathione supplement to S-acetylglutathione in vitro with human cells and in mice. The S-acetylglutathione much more effectively restored intracellular glutathione levels than the regular glutathione (after intracellular levels were reduced by viral infection) - read the study here: http://www.springerlink.com/content/kafjjkger0cg698m/

The authors of that study explain that S-acetylglutathione is readily taken up by cells and converted to reduced glutathione ready for use. Regular glutathione in the bloodstream must be broken down into its constituent amino acids (glycine, glutamic acid, cysteine) and put back together again inside the cell and this is impaired by viral infection - which is obviously a problem for people with illnesses such as ME/CFS which involve chronic viral infection.

Dr. Cheney did used to be very vocal on undenatured whey products but I guess he has just moved on to other things now - last time I checked out his website he was into stem cell therapy and other cutting edge (and expensive) stuff.