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TOPIC: MCS A1 Etiology: References

MCS A1 Etiology: References 8 years 11 months ago #1

MCS A-1 Etiology: Dantoft 2014


Agopyan N et al. Negatively charged 2 and 10 micron particles activate vanilloid receptors, increase cAMP, and induce cytokine release. Tox and Appl Pharm 186(2): 63-76 2003

Apogyan N. et al. Vanilloid receptor activation by 2-and-10-micron particles induces responses leading to apoptosis in human airway epithelial cells. Tox Appl Pharm 192;(1):21-35 2003a

Anand U. et al. TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons. Neurosc Let 438:221-27 2008

Bai N. et al. The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction. Pharmacology and Therapeutics 113:16-29 2007

Bandell M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-57 2004

Bhattacharya M. et al. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl acad Sci USA 105:20015-20 2008

Baulig A.et al.Role of Paris PM 2.5 components in the pro-inflammatory response induced in airway epithelial cells. Tox 261: 126-35 2009

Baulig A. et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells.Am J Physiol. Lung Cell mol Physiol 285 L671-679 2003a

Bautista D. et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124: 1269-82 2006

Bedard A. and Parent A. Evidence of newly generated neurons in the human olfactory bulb. Dev Brain Res 151: 159-68 2004

Bell I. et al. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerances. Int J Psychophys iol 28:23-5 1998

Bell I. Clinically relevant EEG studies and psychophysiological findings: possible neural mechanisms for multiple chemical sensitivity. Toxicol 111:101-17 1996


Bessac B. & Jordt S. Breathtaking TRP channels : TRPA1 and TRPV1 in airway chemosensation and reflex control. Phys 23:360-70 2008

Bessac B. et al. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin invest 118:1899-1910 2008a

Blau J. & Solomon F. Smell and other sensory disturbances in migraine. J Neurol 232:275-76 1985

Block M.L. et al. The outdoor air pollution and brain health workshop. Neurotox 33: 972-84 2012

Block M.L.and Calderon-Garciduenas L. Air pollution: mechanisms of neuroinflammation & CNS disease. Trends Neuro 32(9): 506-16 2009

Block M.L. et al. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons; the role of microglia, phagocytosis, and NADPH oxidase. FASEB 10.1096/fj.041945fje 2004

Bond J.A. et al. Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs. Drug Metab Dispos 16:116-24 1988

Bonvallot V. et al. Organic compounds from diesel exhaust particles elicit a pro-inflammatory response in human airway epithelial cells and induce cytochrome P450 1A1 expression. Am J Resp Cell Mol Biol 25: 515-21 2001

Bonvallot V. et al. Activation of transcription factors by diesel exhaust particles in human bronchial epithelial cells in vitro. Inhal Tox 12:359-64 2000

Boyman O. & Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol 12:180-90 2012

Burtscher H. et al. Characterization of particles in combustion engine exhaust J Aerosol Sci 29:389-96 1998

Burtscher H. and Schmidt-Ott A. In situ measurement of adsorption and condensation of polyaromatic hydrocarbons on ultrafine c particles by means of photoemission. J Aerosol Sci 17:699-703 1986

Caccamo D. et al. Xenobiotic sensor and metabolism related gene variants in environmental sensitivity related illnesses: a survey on the Italian population. Oxidative Medicine and Cellular Longevity Article ID 831969 9 pages Volume 2013 dx.doi.org/10.1155/2013/831969

Cadle S.H et al. Composition of light duty motor vehicle particulat... in the Denver, Colorado area. Env Sc Tech 33;14: 2328-39 1999

Calderon-Garciduenas L. et al. Urban air pollution: influence on olfactory function and pathology in exposed children and young adults. Exp Tox Pathol 62:91-102 2010

Calderon-Garciduenas L. et al. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Tox Pathol 36: 289-310 2008

Calderon-Garciduenas L. et al. Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Tox Pathol 32: 650-58 2004

Calderon-Garciduenas L., Maronpot R.R. et al. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Tox Pathol 31: 524-38 2003

Calderon-Garciduenas L., Mora-Tiscareno A. et al. Respiratory damage in children exposed to urban pollution. Pediatr Pulmonal 36: 148-61 2003

Calderon-Garciduenas L. et al. Air pollution and brain damage. Tox Pathol 30: 373-89 2002

Calderon-Garciduenas L. et al. Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants. Med Hyp 55(5): 373-378 2000

Chin B.Y. et al. Induction of apoptosis by particulate matter; role of TNF-alpha and MAPK. Am j Physiol 275(5 Pt. 1):1942-9 1998

Dai Y. et al. Sensitization of TRPA1 by PAR 2 contributes to the sensation of inflammatory pain. J Clin Invest 117:1979-87 2007

Danahay H. et al. Interleukin 13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 282: L226-36 2002

Daniell W.E. et al. Environmental chemical exposures and disturbances of heme synthesis. EHP 105 (1) Feb 1997

Dantoft T.M. et al. An elevated pro-inflammatory cytokine profile in multiple chemical sensitivity. Psychoneuroendocrinology 40: 140-50 2014
Davies G. & Whyatt J. D. A network-based approach for estimating pedestrian journey-time exposure to air pollution. Science of the Total Environment. 485-486: 62-70 2014
Deering-Rice C. et al. Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Tox 24;6:950-9 2011

Deluca C. et al. Biological definition of multiple chemical sensiti... from redox state and cytokine profiling and not from polymorphisms of xenobiotic metabolizing enzymes. Tox and Appl Pharm 248: 285-92 2010

Elberling J. et al. A twin study of perfume-related respiratory symptoms. Int J Hyg Env H 212: 670-78 2009

Elder A. et al. Translocation of inhaled ultrafine manganese oxide particles in the central nervous system. EHP 114:1172-78 2006

Friedman D. & De ver Dye T. Migraine and the environment. Headache 49: 941-52 2009

Gavett S.H. et al. Capsaicin receptor antagonist and c-fiber depletion reduce pulmonary responses to particulate matter in BALB/c mice. The Toxicologists 18:405 1998

Genter, M.B. Uptake of materials from the nasal cavity into the blood and brain. Ann NY Acad Sc 1170: 623-28 2009

Gerde P. et al. The rapid alveolar absorption of diesel-soot adsorbed benzo[a]pyrene: bioavailability, metabolism, and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 22;5:741-49 2001

Gerde P. et al. Benzo{a}pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 18:1825-32 1997

Gillespie P. et al. Particulate matter neurotoxicity in culture is size dependant. Neurotox 36: 112-17 2013

Hahn M. & Bonkovsky HL. Multiple chemical sensitivity syndrome and porphyria. A note of caution and concern. Arch Int Med 157(3): 281-5 1997

Hayes A. et al. Effects of neonatal administration of capsaicin on nociceptive thresholds in the mouse and rat. J Pharm Pharmacol 33;3:183-85 1981

Hazari M. et al. TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmia in hypertensive rats exposed to diesel exhaust. EHP 119:951-57 2011

Hinman A. et al.TRP channel activation by reversible covalent modification. Proc Nat Acad Sc USA 103:19564-568 2006

Holroyd K. et al. Genetic modeling of susceptibility to nitrogen dioxide-induced lung injury in mice. Am J Physiol 273;1-3:L595-602 1997

Holst H. et al. Increased capsaicin-induced secondary hyperalgesia in patients with multiple chemical sensitivity. Clin J Pain 2:156-62 2011

Ichinose T. et al. Murine strain differences in allergic airway inflammation and immunoglobulin production by a combination of antigen and diesel exhaust particles. Tox 122;3:183-92 1997

Inoue K-i. et al. Effects of nanoparticles on antigen-related airway inflammation in mice. Resp Res 6:106 2005

Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005

Jordt S. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-65 2004

Jung C.G. Psychological Types. Princeton University Press and in the Portable Jung Viking Press 1921

Kelman I. The triggers or precipitants of the acute migraine attack. Cephalagia 27:394-402 2007

Kimata H. Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor, and histamine in patients with self reported multiple chemical sensitivity. Int J Hyg Env H 207:2 159-63 2004.

Kittelson D.B. Engines and nanoparticles: a review. J Aerosol Sci 29: 575-88 1998

Kleeberger S. Genetic susceptibility to ozone exposure. Tox Lett 82-83:295-300 1995

Kleeman M.J. et al. Size and composition distribution of fine particle matter emitted from woodburning, meat charbroiling, and cigarettes. Env Sc Tech 33;20: 3516-23 1999

Kobayashi K. et al. Distinct expression of TRPM8,TRPA1, and TRPV1 in rat primary afferent neurons with adelta/c fibers and colocalization with trk receptors. J Comp Neur 493:596-606 2005

Latremoliere A. & Woolf C. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10;9:895-926 2009

Lewis J. et al. Trigeminal uptake and clearance of inhaled magnesium chloride in rats and mice. Neurotox 26:113-23 2005

Li J. et al. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. EHO 119: 784-93 2011

Lucchini R.G. et al. Neurological impacts from inhalation of pollutants and the nose-brain connection. Neurotox (2011) doi:10.1016/j.neuro.2011.12.001 in press

MCS 9 Etiology:Airway Origins PM and a Defective Scrubber.

MCS 10 Etiology: Credible Proof: The Study of all Studies.

MCS 11 Etiology: PM Trigeminal and Olfactory Pathways.

MCS 15 Etiology: Airway Genetics

Macpherson L. et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-45 2007

Materazzi S. et al. Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain 154: 2750-58 2013

Matsui Y. et al. Tracking the pathway of diesel exhaust particles from the nose to the brain by x-ray florescense analysis. Spectrochimica Acta Part B 64: 796-801 2009

McKeown-Eyssen G. et al. Case control study of genotypes in multipl... CYP2D6, NAT1, NAT2, PON1, PON2, and MTHFR. Int J Epidem 33: 970-78 2004

Meggs W.J. Arch Env H 54(5) 309-11 1999

Meggs W.J. Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Env H Perspect 105(2): 473-78 1997

Meggs W.J. et al. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Tox Clin Tox 34;4: 383 1996

Meggs W.J. Neurogenic Inflammation and sensitivity to environmental chemicals. EHP 101;3:234-38 1993

Meggs W.J. and Cleveland Jr. C.H. Rhinolaryngoscopic examination of patients with multiple chemical sensitivity syndrome. Arch Env H 48: 1-14 1993a

Millqvist E. et al. Changes in level of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals. EHP 113;7: 844-52 2005

Minty A. et al. Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362: 248-50 1993

Miyabara Y. et al. Murine strain differences in airway inflammation caused by diesel exhaust particles. Eur Resp J 11: 291-98 1998

Miyabara Y. et al. Diesel exhaust enhances allergic airway inflamma... and hyperesponsiveness in mice. Am J Resp Crit Care Med 157: 1138-44 1998a

Mohankumar S.M.J. et al. Particulate matter, oxidative stress and neurotoxicity. Neurotox 29: 479-88 2008

Nassini R. et al. The 'headache tree' via umbellone and TRPA1 activates the trigeminovascular system. Brain doi:10 1093/brain/awr272 2011

Nielsen G.D. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. Crit Rev Tox 21:3:183-208 1991

Nogami H. et al. Capsaicin provocation test as a diagnostic method for determining multiple chemical sensitivity. Allergology Int 2: 153-57 2004

Oortgiesen et al. Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons. Am J Physiol Lung Cell Mol Physiol 278: L683-95 2000

Orriols R. et al. Brain Dysfunction in Multiple Chemical Sensitivity. J Neurol Sc 287: 72-78 2009

OSHA: Partial list of chemicals in diesel exhaust.

Oslund K. et al. Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair. AmJ Respir Cell Mol Biol 39:279-88 2008

Pakkanen T.A. et al. Size distributions of mass and chemical compon... in street-level and rooftop PM1 particles in Helsinki. Atmosph Env 37: 1673-90 2003

Parham P. et al. The immune system. 3rd ed. Garland Science, Taylor & France group, LLC 2009

Prior M. et al. Capsaicin pretreatment modifies hydrogen sulphide-induced pulmonary injury in rats. Tox Pathol 18;2:279-88 1990

Punnonen J. et al. Interleukin 13 induces interleukin 4-interdependent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-34 1993

Roy et al. Susceptibility to pollutant-induced airway inflammation is neurogenically mediated. EPA EIMS Metadata report 59754 2000

Ruckerl R et al. Air pollution and inflammation (interleukin 6, C-reactive protein, fibrinogen) in myocardial infarction survivors. EHP 115;7:1072-80 2007

Salmon P. et al. Cognitive abilities mediated by frontal-subcortical circuits. Chapter 5 in: Lichter D.G. & Cummings J.L. editors. Frontal-subcortical circuits in psychiatric and neurological disorders. New York: The Guilford Press: 114-50 2001

Satoh H. et al. Inhibitory effects of capsazepine and SR 48968 on citric acid-induced bronchoconstriction in guinea-pigs. Eur J Pharm 236;3:367-72 1993

Schauer J. et al. Measurement of emissions from air pollution sources. 5. C1-C32 organic compounds from gasoline-powered motor vehicles. Env Sc Tech 36:1169-80 2002

Schauer J. et al. Measurement of emissions from air pollution sources. 3. C1-C29 organic compounds from fireplace combustion of wood. Env Sc Tech 35:1716-28 2001

Schauer J. et al. Measurement of emissions from air pollution sources 2. C1 through C30 organic compounds from medium duty diesel trucks. Env Sc Tech 33:1578-87 1999

Scheerens H. et al. The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways. Br J Pharm 119;8:1665-71 1996

Schnakenberg E. et al. A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Env H 6:6 2007

Society of Automotive Engineers. Schematic of diesel particles and vapor phase compounds. SAE Paper no. 940233 1994

Steerenberg P.A. et al. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res 24: 85-100 1998

Sterner-Kock A. et al. Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J Leukoc Biol 65:1834-40 1999

Tanabe T. et al. Intracellular signalling pathway of substance P-induced superoxide production in human neutrophils. Eur J Pharmacol 299:187-95 1996

Taylor-Clark T. & Undem B. Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol 588;3:423-33 2010

Tran et al. Multiple chemical sensitivity: on the scent of central sensitization. Int J Hyg Ind H 216(2):202-10 2013

US DOT FHA Addendum to the 1997 Federal Highway Cost Allocation Study. Final report. May 2000

Veronesi B. et al. Effects of subchronic exposure to concentrated ambient particles VII Degeneration of dopaminergic neurons in APO E-1 mice. Inhal Tox 17; 4-5: 235-41 2005

Veronesi B. et al. Electrostatic charge activates inflammatory vanilloid (VR1) receptors. Neurotox 24: 463-73 2003

Veronesi B. et al. The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells. Tox and Appl Pharm 178: 144-54 2002a

Veronesi B. et al. Particulate matter inflammation and receptor sensitivity are target cell specific. Inhal Tox 14(2): 159-83 2002b

Veronesi B. and Oortgiesen M. Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotox 22: 795-810 2001

Veronesi B. et al. Vanilloid capsaicin receptors influence inflammatory sensitivity in response to particulate matter. Tox Appl Pharm 15;169(1): 66-76 2000

Veronesi B. et al. Particulate matter initiates inflammatory cytoki... by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Tox and Appl Pharm 154: 106-15 1999a

Veronesi B.et al. Neuropeptides and capsaicin stimulate the release of inflammatory cytokines in a human bronchial epithelial cell line. Neuropep 33;6: 447-56 1999b

Voigt J.M. et al. Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa. J Hystochem Cytochem 41:877-85 1993

Yeadon M. et al. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharm 5;1:39-50 1992

Zhang L. Differential susceptibility to ozone-induced airways hyperreactivity in inbred strains of mice. Exp Lung Res 21;4:503-18 1995

Zhu G. et al. Association of TRPV4 gene polymorphisms with chronic obstructive pulmonary disease. Hum Mol Gen 18(11):2053-62 2009

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