Review Detail
Living in the UK, I obtained the test from ME/CFS specialist Dr. Sarah Myhill, M.D., at a cost of a little over £20. You can also obtain the test directly from Protea biopharma or a handful of distributors in other countries.
The test itself was a very simple matter. I collected a sample of urine in the container provided the first time I visited the bathroom on waking. I then used the pipette type tool to take a smaller sample and add this to the vile containing a special chemical (known as a reagent) that reacts with hydrogen sulfide metabolites. I then turned the vile upside down a couple of times to mix the reagent and urine together and started timing for 3 minutes.
So the test itself was quick, simple, and relatively inexpensive. The tricky part I discovered is interpreting the results. The instruction sheet provides pictures which show viles with sample colours indicating negative, moderate positive, and strong positive results. The problem is that my sample showed a definite change of colour within the 3 minute period but did not match up to any of the pictures. My sample had more of a brown hue than any of the pictures show. Despite this, based on how dark my sample turned I believe my result to have been borderline moderate-strong positive.
After reading others' experiences with the test on various websites and forums it seems my experience is common. Perhaps it is simply a matter of the colour rendering when the instructions leaflet is printed but it is certainly something that Protea biopharma need to look at if the test is to become an approved diagnostic test I would have thought.
Still, I saw a definite colour change towards a darker colour so will take this as further evidence of gut dysbiosis in conjunction with various other tests I have had including CDSA and gut fermentation profile.
If you are a ME/CFS patient and have not had any testing regarding gut dysbiosis I'd certainly recommend the NMT as a cheap and easy home test which can be regarded as an initial screen. A positive looking result could then be followed up with further testing such as those I've mentioned.
Overall rating | 8.0 | |
Ease of use | 10.0 | |
Value for money | 7.0 | |
Usefulness of results | 7.0 | |
Would you recommend? | 8.0 |

Last updated: September 23, 2009
#1 Reviewer - View all my reviews (107)
Neurotoxic Metabolite Test (NMT)
Having suffered from chronic fatigue syndrome for 18 years and had other tests strongly indicating gut dysbiosis I was intrigued to hear about Professor de Meirleir's work and very interested in taking the Neurotoxic Metabolite Test myself.
Living in the UK, I obtained the test from ME/CFS specialist Dr. Sarah Myhill, M.D., at a cost of a little over £20. You can also obtain the test directly from Protea biopharma or a handful of distributors in other countries.
The test itself was a very simple matter. I collected a sample of urine in the container provided the first time I visited the bathroom on waking. I then used the pipette type tool to take a smaller sample and add this to the vile containing a special chemical (known as a reagent) that reacts with hydrogen sulfide metabolites. I then turned the vile upside down a couple of times to mix the reagent and urine together and started timing for 3 minutes.
So the test itself was quick, simple, and relatively inexpensive. The tricky part I discovered is interpreting the results. The instruction sheet provides pictures which show viles with sample colours indicating negative, moderate positive, and strong positive results. The problem is that my sample showed a definite change of colour within the 3 minute period but did not match up to any of the pictures. My sample had more of a brown hue than any of the pictures show. Despite this, based on how dark my sample turned I believe my result to have been borderline moderate-strong positive.
After reading others' experiences with the test on various websites and forums it seems my experience is common. Perhaps it is simply a matter of the colour rendering when the instructions leaflet is printed but it is certainly something that Protea biopharma need to look at if the test is to become an approved diagnostic test I would have thought.
Still, I saw a definite colour change towards a darker colour so will take this as further evidence of gut dysbiosis in conjunction with various other tests I have had including CDSA and gut fermentation profile.
If you are a ME/CFS patient and have not had any testing regarding gut dysbiosis I'd certainly recommend the NMT as a cheap and easy home test which can be regarded as an initial screen. A positive looking result could then be followed up with further testing such as those I've mentioned.