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Tamiflu and antiviral drugs not the answer to flu in children say researchers




Tamiflu medicationSome researchers are warning governments that antiviral drugs have limited effectiveness against both seasonal flu and swine flu and may increase risks rather than benefits, especially in children.

While many countries in the northern hemisphere are stockpiling antiviral drugs such as Tamiflu and Relenza for widespread use against seasonal and pandemic flu some researchers are questioning this approach citing a lack of evidence that use of the drugs has significant benefits.

Research published in the British Medical Journal (BMJ) back in August found that Tamiflu and Relenza rarely prevented complications of the flu in children such as asthma flare-ups and secondary infections requiring antibiotics. Tamiflu is also associated with side-effects such as vomiting and widespread antiviral use may lead to viruses becoming resistant to them according to the paper.

The research was a systematic review and meta-analysis of previous studies which looked at the use of antivirals. Scientists at the University of Oxford, England, led by Dr Matthew Thompson, looked at the results of four trials on the treatment of seasonal flu in 1,766 children between one and 12 and three trials involving the use of antiviral to limit the spread of seasonal flu in 863 children in the same age group.

What Thompson and colleagues found was that while the antiviral drugs reduced the length of time children suffered symptoms of flu by around one day, complications were not reduced and side-effects meant children were often no better off.

The second part of the study revealed that 13 people need to be treated to prevent one additional flu case, meaning antivirals reduce transmission of the influenza virus by only 8%.

Thompson reported that: "Our research is finding for most children these antiviral drugs are probably not going to have much of an effect."

Co-author Dr Carl Heneghan, a GP and clinical lecturer at Oxford University, added that “The strategy of giving out this treatment in a mild infection is inappropriate”.

This study is certainly not the first to urge caution and restraint in the use of these antiviral drugs. In an editorial in 2007, again in the BMJ, it was reported that Japanese authorities had advised against prescribing Tamiflu to adolescents aged 10-19 years. This measure resulted from the suicides of two 14 year olds who jumped to their deaths while taking the drug. Another 52 other deaths (14 in children or adolescents) had been associated with Tamiflu at the time of writing. So there is also concern that the drug causes neuropsychiatric disturbances.

Although the University of Oxford researchers did not look at antiviral effects in the current H1N1 swine flu, they say these drugs are unlikely to help children infected with the virus.

In the BMJ they say “While morbidity and mortality in the current pandemic remain low, a more conservative strategy might be considered prudent, given the limited data, side effects such as vomiting, and the potential for developing resistant strains of influenza.”

They add that parents with sick children should make sure they get plenty of rest and fluids and that they should contact their doctor if the child's condition gets worse.

Natural health experts meanwhile say there are many proven means by which to reduce the risk of contracting flu of any kind and dealing with it if you or your children do. Dr. Joseph Mercola, who runs one of the most popular natural medicine websites on the web, has frequently discussed the importance of vitamin D from sunlight exposure, diet and supplements for maintaining the body's innate immune responses which help us fight off viral infections.

Other sensible measures include using good hygiene, washing hands after being out in public places or around those infected with the flu, getting eight hours of sleep every night, avoiding stress, eating a healthy diet with plenty of whole foods, fruits and vegetables and taking supplements of immune boosting nutrients such as vitamin C and zinc if you know you often catch the flu and are therefore susceptible.

Primary Source: Shun-Shin M Thompson M Heneghan C Perera R Harnden A Mant D (2009) Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials (Online) last accessed 29.10.09 at


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People in this conversation

  • Hi - this is a really interesting article Maff and confirms what I suspected... Just thought I'd let you and others know of something I tried..

    There have been several swine flu outbreaks at my son's school, and I was called to pick him up one morning as he had a sudden high temperature (39.4) and was feeling terrible. When I picked him up he was clearly really very ill - far worse than I'd seen him in years, if ever. As soon as we got home I gave him 4grams of Vitamin C diluted in water, along with 1 paracetomol; he immediately fell asleep for about 2 hours. Throughout the day I gave him more Vitamin C - a total of about 10grams in about 12 hours (though no more paracetomol)and one standard multivitamin and mineral. By the end of the day his temperature was only slightly above normal. Over the next 2 days I continued to give Vitamin C, in 1 gram doses, about 3 - 4 times a day, along with a standard multivitamin and mineral, and although he was weak and exhausted for the next two days he was back at school and fine by Monday. The rest of us in the household were obsessive about hygiene and also took about 4 grams a day in small doses. No-one else became ill.

    Obviously, there was no test to confirm if my son had swine flu, although the NHS questionnaire certainly suggested that he may have. He may have had a self limiting virus that he got rid of quickly.

    In researching Vitamin C through my course I have discovered that not only does Vitamin C enhance immune activity, it also works similarly to tamiflu in high doses, in that it is thought to stop the virus entering cells and also possibly stops it replicating in certain ways. If I had given that amount of Vitamin C normally it would have triggered diarrhoea and cramping; as it was, no one in the family had any gut reactions, suggesting to me that we were using up all the vitamin C and needed it. Vitamin C in very high doses (above 10 grams) can theoretically become pro-oxidant and therefore harmful, although I can find nothing to suggest that it is unsafe at that level for short periods of time.

    In terms of pregnant women (my sister is pregnant currently) I am unable to find definitive confirmation of how much Vitamin C is safe. Certainly I would be nervous of dosing her with that much without more research to back me up. However I suspect, perhaps wrongly, that there may be more research as to the safety of Vitamin C than there is on the current swine flu vaccine.

    I just wonder why there has been no more research on the effects of Vitamin C on the swine flu virus. Could it be anything to do with the fact that I can buy a pot of 250grams of Vitamin C for less than Ăƒâ€šĂ‚Â£10?

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