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Bacterial derived proteoliposome for allergy vaccines

 

 

 

Vaccine. 2006 Apr 12;24 Suppl 2:S2-34-5.

 

Bacterial derived proteoliposome for allergy vaccines.

 

Lastre M, Perez O, Labrada A, Bidot I, Perez J, Bracho G, del Campo J, Perez D, Facenda E, Zayas C, Rodriguez C, Sierra G.

 

Immunology Department, Finlay Institute, P.O. Box 16017, Havana, Cuba. This email address is being protected from spambots. You need JavaScript enabled to view it.

 

One current approach in developing anti allergic vaccines is the use of potent adjuvants, capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable adjuvant. Purified Dermatophagoides siboney (Ds) allergens were mixed with PL and adsorbed into Al(OH)3 and evaluated in mice. The Th1/Th2 responses were measured at classes, subclasses, cytokines, and DTH levels. Anti Ds response was deviated to a Thl pattern, with the production of IgG2a and gamma1FN. A positive DTH response and a dramatic decrease of specific IgE and IL5 were not detected. The low dose was more effective than high dose. These results clearly support the potential use of PL as possible adjuvants for anti-allergic vaccines.

 

PMID: 16823916 [PubMed - in process]

 


 

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