Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$com_exception as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289
Childhood asthma after bacterial colonization of the airway in neonates

Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access

×

Login To Get Involved!


Forgot your username?


Forgot your password?

×

Join Us At EiR Now!

DNRS Roof Banner

 

DNRS Interactive DVD Series & Seminars


Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Childhood asthma after bacterial colonization of the airway in neonates

 

 

 

N Engl J Med. 2007 Oct 11;357(15):1487-95.

 

Childhood asthma after bacterial colonization of the airway in neonates.

 

Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bønnelykke K, Brasholt M, Heltberg A, Vissing NH, Thorsen SV, Stage M, Pipper CB. Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen. This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

BACKGROUND: Pathological features of the airway in young children with severe recurrent wheeze suggest an association between bacterial colonization and the initiating events of early asthma. We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life.

 

METHODS: The subjects were children from the Copenhagen Prospective Study on Asthma in Childhood birth cohort who were born to mothers with asthma. Aspirates from the hypopharyngeal region of asymptomatic 1-month-old infants were cultured for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. Wheeze was monitored prospectively on diary cards during the first 5 years of life. Blood eosinophil count and total IgE and specific IgE were measured at 4 years of age. Lung function was measured and asthma was diagnosed at 5 years of age.

 

RESULTS: Hypopharyngeal samples were cultured from 321 neonates at 1 month of age. Twenty-one percent of the infants were colonized with S. pneumoniae, M. catarrhalis, H. influenzae, or a combination of these organisms; colonization with one or more of these organisms, but not colonization with S. aureus, was significantly associated with persistent wheeze (hazard ratio, 2.40; 95% confidence interval [CI], 1.45 to 3.99), acute severe exacerbation of wheeze (hazard ratio, 2.99; 95% CI, 1.66 to 5.39), and hospitalization for wheeze (hazard ratio, 3.85; 95% CI, 1.90 to 7.79). Blood eosinophil counts and total IgE at 4 years of age were significantly increased in children colonized neonatally with S. pneumoniae, M. catarrhalis, H. influenzae, or a combination of these organisms, but specific IgE was not significantly affected. The prevalence of asthma and the reversibility of airway resistance after beta2-agonist administration at 5 years of age were significantly increased in the children colonized neonatally with these organisms as compared with the children without such colonization (33% vs. 10% and 23% vs. 18%, respectively).

 

CONCLUSIONS: Neonates colonized in the hypopharyngeal region with S. pneumoniae, H. influenzae, or M. catarrhalis, or with a combination of these organisms, are at increased risk for recurrent wheeze and asthma early in life. Copyright 2007 Massachusetts Medical Society.

 

PMID: 17928596 [PubMed - in process]

 

Full Article Available Online

 


 

 

Related Articles:

 

Home Testing & Sanitizer:
 

 

 

 

 

ADVERTISEMENT

 

  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner