Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access

×

Login To Get Involved!


Forgot your username?


Forgot your password?

×

Join Us At EiR Now!

DNRS Roof Banner

 


 

Universal AJAX Live Search

Search - Categories
Search - Contacts
Search - Content
Search - Newsfeeds
Search - Weblinks

Exposure to Traffic Related Particles and Endotoxin During Infancy Is Associated With Wheezing

 

 

 

Am J Respir Crit Care Med. 2009 Sep 10. [Epub ahead of print]

 

Exposure to Traffic-Related Particles and Endotoxin During Infancy Is Associated With Wheezing At Age Three.

 

Ryan PH, Bernstein DI, Lockey J, Reponen T, Levin L, Grinshpun S, Villareal M, Khurana Hershey GK, Burkle J, Lemasters G. Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States.

 

 

RATIONALE: Murine models demonstrate a synergistic production of reactive oxygen species upon co-exposure to diesel exhaust particles and endotoxin.

 

OBJECTIVES: It was hypothesized that co-exposure to traffic-related particles and endotoxin would have an additive effect on persistent wheezing during early childhood.

 

METHODS: Persistent wheezing at age 36 months was assessed in the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk birth cohort. A time weighted average exposure to traffic-related particles was determined by applying a land-use regression model to the homes, daycares, and other locations where children spent time from birth through age 36 months. Indoor levels of endotoxin were measured from dust samples collected prior to age 12 months. The relationship between dichotomized (< / >/=75th percentile) traffic-related particle and endotoxin exposure and persistent wheezing, controlling for potential covariates, was examined.

 

MEASUREMENTS AND MAIN RESULTS: Persistent wheezing at age 36 months was significantly associated with exposure to increased levels of traffic-related particles prior to age 12 months (OR = 1.75, 95%CI 1.07 â 2.87). Co-exposure to endotoxin had a synergistic effect with traffic exposure on persistent wheeze (OR = 5.85, 95% CI 1.89-18.13) after adjustment for significant covariates.

 

CONCLUSIONS: The association between traffic-related particle exposure and persistent wheezing at age 36 months is modified by exposure to endotoxin. This finding supports prior toxicological studies demonstrating a synergistic production of ROS after co-exposure to DEP and endotoxin. The effect of early versus later exposure to traffic-related particles, however, remains to be studied due to the high correlation between exposure throughout the first three years of life.

 

PMID: 19745206 [PubMed - as supplied by publisher]

 


 

Please Help Support EiR with a Positive Google Review!

Review 'The Environmental Illness Resource' (EiR) on Google

 

If you like EiR and / or enoyed this content; please help us keep going by leaving a Positive Google Review:
Review EiR on Google NOW!

P.S. This is entirely secure, we collect no data other than what is freely available from Google and you can remain anonymous!

 


Related Articles:

 

Mold Testing & Sanitizer:

 

 

 

 

ADVERTISEMENT

 

  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner

View the very BEST Environmental Illness Videos!

1. Your Health is Governed by Your Environment | Prof. BM Hegde | TEDx Talk

2. Demystifying Multiple Chemical Sensitivity

3. Social Determinants of Health - An Introduction