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Systemic contact dermatitis after oral exposure to nickel




Contact Dermatitis. 2006 Feb;54(2):79-86.


Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis.


Jensen CS, Menne T, Johansen JD.


National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark. This email address is being protected from spambots. You need JavaScript enabled to view it.


Systemic contact dermatitis can be elicited experimentally in nickel-sensitive individuals by oral nickel exposure. A crucial point interpreting such experiments has been the relevance of nickel exposure from drinking water and diet. The aim of this meta-analysis study on former nickel-exposure investigations was to provide the best possible estimation of threshold values of nickel doses that may cause systemic contact dermatitis in nickel-sensitive patients. 17 relevant investigations were identified, and statistical analyses were performed in a stepwise procedure. 9 studies were included in the final dose-response analysis, which divided the studies into a homogenous middle group of 5 studies and 2 groups of 2 studies with a higher and lower response frequency, respectively, described by logistic dose-response curves shifted in parallel. On the basis of these curves, calculations were made of the doses that, theoretically, would cause systemic contact dermatitis in exposed nickel-sensitive patients. The results from the 2 most sensitive groups show that 1% of these individuals may react with systemic contact dermatitis at normal daily nickel exposure from drinking water and diet, i.e. 0.22-0.35 mg nickel.


Publication Types:


PMID: 16487279 [PubMed - indexed for MEDLINE]

Full Article Available Online




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