Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access


Login To Get Involved!

Forgot your username?

Forgot your password?


Join Us At EiR Now!

DNRS Roof Banner


DNRS Interactive DVD Series & Seminars

Thimerosal allergy and clinical relevance in Thailand




J Med Assoc Thai. 2007 Sep;90(9):1775-9.


Thimerosal allergy and clinical relevance in Thailand.


Wattanakrai P, Rajatanavin N. Division of Dermatology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.



BACKGROUND: Thimerosal or merthiolate is used as an antiseptic and a preservative in topical medicaments, cosmetics, and vaccines. Thimerosal is known to cause delayed type hypersensitivity. However, there is argument about the clinical relevance and risk of using thimerosal-preserved products in thimerosal allergic individuals.


OBJECTIVE: Retrospective review of patch test results from the Ramathibodi Hospital patch test clinic to determine the prevalence and relevance of allergic reactions to thimerosal in Thailand.


MATERIAL AND METHOD: During a 5-year period, thimerosal was patch tested in all patients tested for possible allergic contact dermatitis. Thimerosal was the second most common allergen causing a positive patch test reaction.


RESULTS: Of the 433 patients tested, 46 (10.62%) were positive to thimerosal. However, despite the high prevalence of positive reactions none was clinically relevant to their present dermatitis, none of the patients reported reactions to vaccination or cross-reaction to piroxicam.


CONCLUSION: There was a high rate of sensitization to thimerosal in Thai patients, but were of little clinical relevance. The author does not advise thimerosal allergic individuals to avoid vaccination, although the small risk of local dermatitis should be pointed out. The topical use of thimerosal containing antiseptics should be avoided.


PMID: 17957918 [PubMed - in process]




Related Articles:


Home Testing & Sanitizer:







  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner