A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity

Acta Neurobiol Exp (Wars). 2009;69(2):189-97.

A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity.

Geier DA, Kern JK, Geier MR. Institute of Chronic Illnesses, Inc., Silver Spring, Maryland, USA; This email address is being protected from spambots. You need JavaScript enabled to view it..

Dental amalgams containing 50% mercury (Hg) have been used in dentistry for the last 150 years, and Hg exposure during key developmental periods was associated with autism spectrum disorders (ASDs). This study examined increased Hg exposure from maternal dental amalgams during pregnancy among 100 qualifying participants born between 1990-1999 and diagnosed with DSM-IV autism (severe) or ASD (mild). Logistic regression analysis (age, gender, race, and region of residency adjusted) by quintile of maternal dental amalgams during pregnancy revealed the ratio of autism:ASD (severe:mild) were about 1 (no effect) for </=5 amalgams and increased for>=6 amalgams. Subjects with>=6 amalgams were 3.2-fold significantly more likely to be diagnosed with autism (severe) in comparison to ASD (mild) than subjects with </=5 amalgams. Dental amalgam policies should consider Hg exposure in women before and during the child-bearing age and the possibility of subsequent fetal exposure and adverse outcomes.

PMID: 19593333 [PubMed - in process]