Frequency of CD4+ CD25 high Regulatory T Cells in Peripheral Blood of Egyptian Children With Autism

J Child Neurol. 2009 Aug 27. [Epub ahead of print]

Frequency of CD4+CD25high Regulatory T Cells in Peripheral Blood of Egyptian Children With Autism.

Mostafa GA, Shehab AA, Fouad NR. Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Autoimmunity may have a role in autism, although the origins of autoimmunity in autism are unknown. CD4(+)CD25(high) regulatory T cells play an important role in the establishment of immunological self-tolerance, thereby preventing autoimmunity. The authors are the first to study the frequency of CD4(+)CD25(high) regulatory T cells in the blood of 30 autistic and 30 age- and sex-matched healthy children. Patients with autism had significantly lower frequency of CD4(+)CD25(high) regulatory T cells than healthy children (P < .001). These cells were deficient in 73.3% of children with autism. Autistic patients with allergic manifestations (40%) and those with a family history of autoimmunity (53.3%) had a significantly lower frequency of CD4(+)CD25(high) regulatory T cells than those without (P < .01 and P < .001, respectively). In conclusion, CD4(+)CD25(high) regulatory T cells are deficient in many children with autism. Deficiency of these cells may contribute to autoimmunity in a subgroup of children with autism. Consequently, CD4(+)CD25(high) regulatory T cells could be new potential therapeutic targets in these patients.

PMID: 19713552 [PubMed - as supplied by publisher]