Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access

×

Login To Get Involved!


Forgot your username?


Forgot your password?

×

Join Us At EiR Now!

DNRS Roof Banner

 



New DNRS 2.0 Available NOW! Improved via Research & Patient Feedback.

Universal AJAX Live Search

Search - Categories
Search - Contacts
Search - Content
Search - Newsfeeds
Search - Weblinks

Insulin-like growth factor delivery across the blood-brain barrier

 

 

 

Chemotherapy. 2006;52(6):279-81. Epub 2006 Sep 27.

 

Insulin-like growth factor delivery across the blood-brain barrier. Potential use of IGF-1 as a drug in child neurology.

 

Riikonen R. Children's Hospital, University of Kuopio, Kuopio, Finland. This email address is being protected from spambots. You need JavaScript enabled to view it.

 

BACKGROUND: Recent data indicate that insulin-like growth factor-1 (IGF-1) can cross the blood-brain barrier when bound to binding proteins. IGF-1 is very important for early brain development, myelination and survival of cerebellar neurons. It is antiapoptotic and is important for synaptic development. The aim of this study was to identify neurological conditions with low CNS IGF-1. METHODS: Levels of CSF IGF-1 were determined by radio-immunoassay (Mediagnost, Tubingen, Germany). RESULTS: Levels of CSF IGF-1 were low in some progressive diseases of white matter and the cerebellum. In some other diseases not involving cerebellum or white matter, CSF IGF-1 was normal. CONCLUSIONS: Our findings might pave the way for rational therapy in patients with neurodegeneration. Patients with low CNS IGF-1 might be candidates for IGF-1 therapy.

 

PMID: 17008777 [PubMed - indexed for MEDLINE]


Full Article Available Online

 


 

Please Help Support EiR with a Positive Google Review!

Review 'The Environmental Illness Resource' (EiR) on Google

 

If you like EiR and / or enoyed this content; please help us keep going by leaving a Positive Google Review:
Review EiR on Google NOW!

P.S. This is entirely secure, we collect no data other than what is freely available from Google and you can remain anonymous!

 


Related Articles:

 

Mold Testing & Sanitizer:

 

 

 

 

ADVERTISEMENT

 

  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner

View the very BEST Environmental Illness Videos!

1. Your Health is Governed by Your Environment | Prof. BM Hegde | TEDx Talk

2. Demystifying Multiple Chemical Sensitivity

3. Social Determinants of Health - An Introduction