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Oxidative stress in Egyptian children with autism: relation to autoimmunity



J Neuroimmunol. 2009 Dec 23. [Epub ahead of print]

Oxidative stress in Egyptian children with autism: relation to autoimmunity.

Mostafa GA, El-Hadidi ES, Hewedi DH, Abdou MM. Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

We are the first to study the relationship between oxidative stress (by measuring plasma F2-isoprostane, as a marker of lipid peroxidation, and glutathione peroxidase, as an antioxidant enzyme) and autoimmunity (as indicated by serum antineuronal antibodies) in a group of 44 Egyptian autistic children and 44 healthy matched-children. Our results showed that oxidative stress was found in 88.64% of autistic children. Oxidative stress, resulting from elevated plasma F2-isoprostane and/or reduced glutathione peroxidase, had significant risk for antineuronal positivity, which was found in 54.5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37-112.10 and 1.21-34.19, respectively). Conclusions: the strong association between oxidative stress and autoimmunity in autistic children may indicate the possible role of oxidative stress, through induction of autoimmunity, in some autistic patients. Therefore, studies considering the role of antioxidants and immunotherapy in amelioration of autistic manifestations are recommended. Copyright © 2009 Elsevier B.V. All rights reserved.

PMID: 20036015 [PubMed - as supplied by publisher]



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  • Oxidative stress and the depletion of endogenous antioxidants (those produced in the body such as glutathione) along with signs of autoimmunity have been found in numerous studies of autistic children. It is a poor state of affairs when such evidence is ignored. Only doctors and health care professionals in private practice who approach autism biomedically (such as those belonging to DAN!) routinely use antioxidants and immunotherapy when treating autistic patients but without large studies this use is speculative and considered investigational. The authors of this study are right to recommend studies to investigate the role antioxidants and immunotherapy can play in treating autism.

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