Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access


Login To Get Involved!

Forgot your username?

Forgot your password?


Join Us At EiR Now!

DNRS Roof Banner


DNRS Interactive DVD Series & Seminars

Searching for ways out of the autism maze: genetic, epigenetic and environmental clues




Trends Neurosci. 2006 Jun 27; [Epub ahead of print]


Searching for ways out of the autism maze: genetic, epigenetic and environmental clues.


Persico AM, Bourgeron T.


Laboratory of Molecular Psychiatry and Neurogenetics, University 'Campus Bio-Medico', Via Longoni 83, I-00155, Rome, Italy; IRCCS 'Fondazione Santa Lucia', Department of Experimental Neurosciences, Via del Fosso di Fiorano 64/65, I-00143, Rome, Italy.


Our understanding of human disorders that affect higher cognitive functions has greatly advanced in recent decades, and over 20 genes associated with non-syndromic mental retardation have been identified during the past 15 years. However, proteins encoded by 'cognition genes' have such diverse neurodevelopmental functions that delineating specific pathogenetic pathways still poses a tremendous challenge. In this review, we summarize genetic, epigenetic and environmental contributions to neurodevelopmental alterations that either cause or confer vulnerability to autism, a disease primarily affecting social cognition. Taken together, these results begin to provide a unifying view of complex pathogenetic pathways that are likely to lead to autism spectrum disorders through altered neurite morphology, synaptogenesis and cell migration. This review is part of the INMED/TINS special issue Nature and nurture in brain development and neurological disorders, based on presentations at the annual INMED/TINS symposium ().


PMID: 16808981 [PubMed - as supplied by publisher]




Related Articles:


Home Testing & Sanitizer:







  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner