Dig Liver Dis. 2006 Dec;38 Suppl 2:S261-5.
Antibiotic resistance: the pros and cons of probiotics.
Courvalin P. Unite des Agents Antibacteriens, Institut Pasteur, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, France.
For the prevention of intestinal disorders, probiotics can be rendered multidrug resistant to survive in the presence of co-administered antibiotics. This generates the possibility of resistance transfer from the probiotic to human bacterial pathogens, either directly or indirectly via the commensal flora. This article reviews the experiments to be performed and the criteria for assessment of safety of antibiotic resistant probiotics.