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Fungicidal and Cytotoxic Activity of a Capsicum chinense Defensin Expressed by Endothelial Cells

 

 

 

 

Biotechnol Lett. 2006 Jun 23; [Epub ahead of print]

 

Fungicidal and Cytotoxic Activity of a Capsicum chinense Defensin Expressed by Endothelial Cells.

 

Anaya-Lopez JL, Lopez-Meza JE, Baizabal-Aguirre VM, Cano-Camacho H, Ochoa-Zarzosa A.

 

Centro Multidisciplinario de Estudios en Biotecnologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolas de Hidalgo, Apdo. Postal 53, Administracion Chapultepec, C.P. 58262, Morelia, Michoacan, Mexico, This email address is being protected from spambots. You need JavaScript enabled to view it. .

 

Plant defensins are antimicrobial peptides that exhibit mainly antifungal activity against a broad range of plant fungal pathogens. However, their actions against Candida albicans have not been extensively studied. The mRNA for gamma-thionin, a defensin from Capsicum chinense, has been expressed in bovine endothelial cells. The conditioned medium of these cells showed antifungal activity on germ tube formation (60-70% of inhibition) and on the viability of C. albicans (70-80% of inhibition). Additionally, C. albicans was not able to penetrate transfected cells. Conditioned medium from these cells also inhibited the viability (80%) of the human tumor cell line, HeLa.

 

PMID: 16794772 [PubMed - as supplied by publisher]


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