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High intestinal IgA associates with reduced risk of IgE associated allergic diseases

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High intestinal IgA associates with reduced risk of IgE associated allergic diseases

 

 

 

Pediatr Allergy Immunol. 2009 Jun 26. [Epub ahead of print]

 

High intestinal IgA associates with reduced risk of IgE-associated allergic diseases.

 

Kukkonen K, Kuitunen M, Haahtela T, Korpela R, Poussa T, Savilahti E. The Skin and Allergy Hospital, Department of Pediatric Allergology, University of Helsinki, Finland.

 

 

Background: Development of oral tolerance and its stimulation by probiotics are still incomprehensible. Microbial stimulation of the gut may induce a subtle inflammation and induce secretion of mucosal IgA, which participates in antigen elimination.

 

Methods: In a cohort of allergy-prone infants receiving probiotics and prebiotics or placebo we studied intestinal IgA and inflammation in the development of eczema, food allergy, asthma, and rhinitis (allergic diseases). We performed a nested unmatched case-control study of 237 infants participating in a randomized double-blind placebo-controlled allergy-prevention trial using a combination of four probiotic strains pre-natally and during 6 months form birth. We measured faecal IgA, alpha1-antitrypsin (alpha1-AT), tumour necrosis factor-alpha (TNF-alpha), and calprotectin at the age of 3 and 6 months.

 

Results: By age 2 yr, 124 infants had developed allergic disease or IgE-sensitization (cases) and 113 had not (controls). In infants with high faecal IgA concentration at the age of 6 months, the risk of having any allergic disease before the age of 2 yr tended to reduce [odds ratio (OR: 0.52)] and the risk for any IgE-associated (atopic) disease reduced significantly (OR: 0.49). High faecal calprotectin at the age of 6 months associated also with lower risk for IgE-associated diseases up to age 2 yr (OR: 0.49). All faecal inflammation markers (alpha1-AT, TNF-alpha, and calprotectin) correlated positively with faecal IgA (p < 0.001). Probiotics tended to augment faecal IgA (p = 0.085) and significantly increased faecal alpha1-AT (p = 0.001).

 

Conclusions: High intestinal IgA in early life associates with minimal intestinal inflammation and indicates reduced risk for IgE-associated allergic diseases.

 

PMID: 19566584 [PubMed - as supplied by publisher]

 


 

 

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