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Inhibitory effect of nicotinamide on enzymatic activity of selected fungal strains




Mycoses. 2009 Sep 16. [Epub ahead of print]


Inhibitory effect of nicotinamide on enzymatic activity of selected fungal strains causing skin infection.


Ciebiada-Adamiec A, Małafiej E, Ciebiada I. Department of Clinical Microbiology, Polish Mother's Hospital Research Institute, Łódź, Poland.



Pathogenicity of fungi is connected with their ability to easily penetrate the host tissues, survive in the infected host organism and use the elements of the host tissues as nutrients. Hence, the co-occurrence of pathogenic properties with the high enzymatic activity, which is manifested through the production of various enzymes including extracellular enzymes, was observed. It can be expected that it is possible to decrease fungal pathogenicity by lowering their enzymatic activity. The aim of the study was to determine the effect of nicotinamide on enzymatic activity of the fungi, which are most frequently isolated in cases of skin infection. Enzymatic activity was analysed using 15 Candida albicans, 15 Trichophyton rubrum and 15 Trichophyton mentagrophytes strains. The strains used for the study were collected from the current diagnostic material. API ZYM tests were used in diagnostic analysis. MICs of nicotinamide were determined by the macrodilution method in liquid medium. In the case of Candida strains, the presence of nicotinamide in the broth had a significant effect on the decrease of enzymatic activity (P < 0.05) of esterase (C4), esterase lipase (C-8), valin-arylamidase, acid phosphatase and alpha-glycosydase. A considerably stronger effect of nicotinamide was observed in the case of dermatophytes (P < 0.005). Its action led to a decrease in the activity of all the enzymes under study except alpha-glucosidase produced by T. rubrum strains. Thus, nicotinamide exhibited biological activity towards C. albicans, T. rubrum and Trichophyton mentagrophytes, which resulted in a decrease in the activity of enzymes produced by the fungi.


PMID: 19761490 [PubMed - as supplied by publisher]



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  • Nicotinamide is a form of vitamin B3 found in the body. It is produced in the body from the conversion of primary dietary form of B3 (niacin).

    This research is interesting as niacinamide is widely and cheaply available as a nutritional supplement so could be a cost-effective addition to the anti-Candida and general anti-fungal armoury. The reduction in fungal enzyme activity also seems to be a unique mechanism amongst dietary and nutritional supplement interventions. Others include garlic and various plant oils (e.g. oregano, clove) which directly kill Candida and other fungi, and biotin (another B vitamin) which inhibits the formation of hyphae, the branching filaments produced by Candida species that can penetrate soft tissue (and may cause leaky gut syndrome in the case of intestinal Candida).

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