Current progress in the pharmacological therapy of fibromyalgia

Expert Opin Investig Drugs. 2009 Sep 7. [Epub ahead of print]

Current progress in the pharmacological therapy of fibromyalgia.

Rao SG. Cypress Bioscience, Inc., 4350 Executive Drive, Suite 325, San Diego, CA 92121, USA +1 858 452 2323, ext 132 ; +1 858 452 1222 ; This email address is being protected from spambots. You need JavaScript enabled to view it..

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder often associated with fatigue, dyscognition, and sleep disturbances. Recent research advances highlight a critical role for aberrant central pain processing in FM, and, consistent with these data, the first three drugs approved by the FDA for FM over the past 2 years have a predominantly central mode of action. The first drug, pregabalin, may counteract central pain transmission by inhibiting presynaptic release of excitatory neurotransmitters, including substance P and glutamate. The serotonin-norepinephrine reuptake inhibitors duloxetine and milnacipran have been approved more recently and are believed to reduce pain by increasing serotonin and norepinephrine concentrations in descending inhibitory pain pathways. Agents with multiple other mechanisms of action are in development and promise an assortment of therapeutic options for this complex disorder in the near future.

PMID: 19732029 [PubMed - as supplied by publisher]