Social Links

Follow on Facebook Follow on TwitterFollow EiR on PinterestFollow EiR on Instagram

Xpert Access

×

Login To Get Involved!


Forgot your username?


Forgot your password?

×

Join Us At EiR Now!

DNRS Roof Banner

 

Universal AJAX Live Search

Search - Categories
Search - Contacts
Search - Content
Search - Newsfeeds
Search - Weblinks

Potential therapeutic targets in irritable bowel syndrome

 

 

 

 

Expert Opin Ther Targets. 2005 Oct;9(5):1079-95.

 

Protease-activated receptors: potential therapeutic targets in irritable bowel syndrome?

 

Gloro R, Ducrotte P, Reimund JM. Centre Hospitalier Universitaire de Caen, Service d'Hepato-Gastro-Enterologie et Nutrition, Avenue de la Cote de Nacre, 14033 Caen Cedex, France.

 

Protease-activated receptors (PARs) are a family of four G-protein-coupled receptors (PAR-1 to PAR-4) activated by the proteolytic cleavage of their N-terminal extracellular domain. This activation first involves the recognition of the extracellular domain by proteases, such as thrombin, but also trypsin or tryptase which are particularly abundant in the gastrointestinal tract, both under physiological circumstances and in several digestive diseases. Activation of PARs, particularly of PAR-1 and -2, modulates intestinal functions, such as gastrointestinal motility, visceral nociception, mucosal inflammatory response, and epithelial functions (intestinal secretion and permeability). As these physiological properties have been shown to be altered in various extents and combinations in different clinical presentations of irritable bowel syndrome, PARs appear as putative targets for future therapeutic intervention in these patients.

 

PMID: 16185159 [PubMed - indexed for MEDLINE]

 

Full Article Available Online

 

 

 

{mosgoogle}

 

{mos_sb_discuss:11}

 


 

Please Review The Environmental Illness Resource on Google or FacebookPlease Help Support EiR with a Positive Google or Facebook Page Review!

If you like EiR and / or enoyed this content; please help us keep going by leaving a Positive Google Review:

https://g.page/r/CbAgn_56aqWaEAI/review 

OR:

Facebook: https://www.facebook.com/ei.resource

P.S. This is entirely secure, we collect no data other than what is freely available from Google and you can remain anonymous!

 


Related Articles:

 

Mold Testing & Sanitizer:

 

 

 

 

ADVERTISEMENT

 

  • No comments found

Leave your comments

Post comment as a guest

0 Character restriction
Your text should be more than 25 characters
Your comments are subjected to administrator's moderation.
terms and condition.

Adsense Responsive BottomBanner