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Restless Legs Syndrome in Patients with Irritable Bowel Syndrome

 

 

 

 

Dig Dis Sci. 2007 Oct 13; [Epub ahead of print]

 

Restless Legs Syndrome in Patients with Irritable Bowel Syndrome: Response to Small Intestinal Bacterial Overgrowth Therapy.

 

Weinstock LB, Fern SE, Duntley SP. Washington University School of Medicine, 11525 Olde Cabin Road, St. Louis, MO, 63141, USA, This email address is being protected from spambots. You need JavaScript enabled to view it. .

 

 

Background Small intestinal bacterial overgrowth (SIBO) occurs in irritable bowel syndrome (IBS) and fibromyalgia. Since restless legs syndrome (RLS) occurs with fibromyalgia, a link between IBS, SIBO, and RLS was studied.

 

Methods: BS patients with abnormal lactulose breath tests received rifaximin 1,200 mg day(-1) for 10 days, followed by tegaserod 3 mg, long-term, and 1 month of zinc 220 mg day(-1) and once-daily probiotic (N = 11) or rifaximin monotherapy (N = 2). IBS symptom improvement was assessed after rifaximin. RLS symptoms, IBS symptoms, and overall IBS global improvement were assessed at last posttreatment visit: 8/10 patients were followed long-term (mean, 139 days; range, 54-450 days).

 

Results: Ten of 13 patients exhibited >/=80% improvement from baseline in RLS symptoms. Five maintained complete resolution of RLS symptoms. Global gastrointestinal symptom improvement was great (n = 6), moderate (n = 5), or mild (n = 2).

 

Conclusion: This study suggests that SIBO associated with IBS may be a factor in some RLS patients and SIBO therapy provides long-term RLS improvement.

 

PMID: 17934858 [PubMed - as supplied by publisher]

 

 

 

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