Somatic comorbidities in irritable bowel syndrome: fibromyalgia and chronic fatigue syndrome

Gastroenterol Clin Biol. 2009 Feb;33 Suppl 1:S17-25.

Somatic comorbidities in irritable bowel syndrome: fibromyalgia, chronic fatigue syndrome, and interstitial cystitis

Mathieu N. Clinique Universitaire d'Hépato-Gastroentérologie, Pôle DIGIDUNE, Centre Hospitalo-universitaire de Grenoble, France. This email address is being protected from spambots. You need JavaScript enabled to view it.

Fibromyalgia, chronic fatigue syndrome, and interstitial cystitis frequently overlap with irritable bowel syndrome (IBS). There is a positive correlation between the incidence of these comorbidities and increased health care seeking, reduction in quality of life, and higher levels of mood disorders, which raises the question of a common underlying pathophysiology. A possible central hypersensitization disorder seems to be particularly involved in the dysfunction of bidirectional neural pathways and viscerovisceral cross-interactions within the CNS, thus explaining these many extraintestinal manifestations in IBS.

PMID: 19303534 [PubMed - in process]