Aliment Pharmacol Ther. 2009 Oct 26. [Epub ahead of print]
Clinical trial: the effect of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome (IBS) - a randomized, double-blind, controlled study.
Simrén M, Ohman L, Olsson J, Svensson U, Ohlson K, Posserud I, Strid H. Dept of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
BACKGROUND: The effects of probiotic bacteria in IBS remain controversial.
AIM: To study the effect of a probiotic product on IBS symptoms.
METHODS: We randomized 74 IBS patients to receive eight weeks of daily treatment with 400 ml milk fermented with the yoghurt bacteria and containing Lactobacillus paracasei, ssp. paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 (Cultura(R); active) or acidified milk without these bacteria (control). The primary endpoint was the proportion of subjects reporting adequate relief of their IBS symptoms at least 50% of the weeks. IBS symptom severity, psychological symptoms, and quality of life were assessed.
RESULTS: The proportion of responders was 38% (14/37 patients) in the active group and 27% (10/37 patients) in the control group (p=0.3). IBS symptom severity improved significantly in both groups during the treatment period. This change was greater in the active group during the first two weeks, but thereafter no significant group differences were seen.
CONCLUSION: We could not detect a clearly positive effect of a fermented milk containing three probiotic bacteria on GI symptoms in IBS patients compared to the control treatment. However, a trend towards a more favorable effect during the first weeks was seen in the active group.
PMID: 19863495 [PubMed - as supplied by publisher]
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