Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

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Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289
Acetaldehyde induced Barrier Disruption and Paracellular Permeability in Caco2 Cell Monolayer

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Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$url_alias as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Non-static method SefAdvanceContent::build() should not be called statically in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/build.php on line 187

Strict Standards: Accessing static property SefAdvanceConfig::$home as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$uniqitem as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$inc_cat as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_cache as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_rewrite as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sufix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Strict Standards: Accessing static property SefAdvanceConfig::$sef_suffix as non static in /home/customer/www/ei-resource.org/public_html/components/com_sefadvance/config.php on line 289

Acetaldehyde induced Barrier Disruption and Paracellular Permeability in Caco2 Cell Monolayer

 

 

 

 

Methods Mol Biol. 2008;447:171-83.

 

Acetaldehyde-induced Barrier Disruption and Paracellular Permeability in Caco-2 Cell Monolayer.

 

Rao RK. University of Tennessee Health Science Center, Department of Physiology, Memphis, TN, USA.

 

 

A significant body of evidence indicates that endotoxemia plays a crucial role in the pathogenesis of alcoholic liver disease. There are several possible factors that may be involved in inducing alcoholic endotoxemia, but increased intestinal permeability to enteric endotoxins appears to be the major contributing factor. In the normal gut, the epithelial barrier function prevents diffusion of toxins across the epithelium. However, the barrier is disrupted in patients with alcoholic liver disease. We showed that acetaldehyde disrupts intestinal epithelial tight junctions and increases paracellular permeability to endotoxins in Caco-2 cell monolayer, the extensively studied model of the differentiated intestinal epithelium. The mechanisms involved in acetaldehyde-induced increase in intestinal permeability to endotoxins can be elucidated in this model of the intestinal epithelium.

 

 

 

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