J Neuropsychiatry Clin Neurosci. 2007 Spring;19(2):179-186.


Antidepressant Effects of High and Low Frequency Repetitive Transcranial Magnetic Stimulation to the Dorsolateral Prefrontal Cortex: A Double-Blind, Randomized, Placebo-Controlled Trial.


Stern WM, Tormos JM, Press DZ, Pearlman C, Pascual-Leone A. Center for Non-Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston MA 02215. This email address is being protected from spambots. You need JavaScript enabled to view it. .


Repetitive transcranial magnetic stimulation (rTMS) has antidepressant effects in patients with major depressive disorder. The mechanisms of action and optimal stimulation parameters remain unclear. To test the hypothesis that rTMS exerts antidepressant effects either by enhancing left dorsolateral prefrontal cortex (DLPFC) excitability or by decreasing right DLPFC excitability, the authors studied 45 patients with unipolar recurrent major depressive disorder in a double-blind, randomized, parallel group, sham-controlled trial. Patients were randomized to receive 1 Hz or 10 Hz rTMS to the left DLPFC, 1 Hz to the right DLPFC or sham TMS. Left 10 Hz and right 1 Hz rTMS showed similar significant antidepressant effects. Other parameters led to no significant antidepressant effects.


PMID: 17431065 [PubMed - as supplied by publisher]










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