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Deficits in development following prenatal and neonatal exposure to low dose bisphenol A





Neuroscience. 2008 Dec 27. [Epub ahead of print]


Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A


.Zhou R, Zhang Z, Zhu Y, Chen L, Sokabe M, Chen L. Laboratory of Reproductive Medicine, Nanjing Medical University, Hanzhong Road 140, Jiangsu, China; Department of Physiology, Nanjing Medical University, Hanzhong Road 140, Jiangsu, China.



Prenatal and neonatal exposure to relatively low-dose bisphenol-A (BPA, 20 mug/kg/day) causes hyper-locomotion of male rat offspring. This research investigated the developmental pattern of activity-dependent synaptic plasticity in dorsolateral (DL) striatum, a cellular basis for motor controlling, in male rat offspring with hyper-locomotion. High frequency stimulation (HFS, four-pulse bursts at 100 Hz) was undertaken to induce long-term potentiation (LTP) and long-term depression (LTD) in corticostriatal synapse during postnatal day (PD) 10-32. Herein, we show that in control rats HFS induces LTP during PD12-14 and LTD during PD24-32. Strikingly, the prenatal and neonatal exposure to low-dose BPA resulted in delay of LTP induction during PD21-32, showing a reversal of LTD induction. In addition, in PD28 BPA-rats basal population spike (PS) amplitude was increased with reduction of paired-pulse facilitation (PPF) compared to the same age control rats. Acute application of the dopamine 1 receptor (D1R) antagonist SCH23390 in slices obtained from PD28 BPA-rats inhibited not only the PS-potentiation and PPF-induction but also the induction of LTP. Furthermore, the dopamine 2 receptor (D2R) agonist quinpirole recovered the LTD induction in PD28 BPA-rats, which was D1R-dependent and metabotropic glutamate receptor-dependent. In PD28 control rats, the blockade of D2R by l-sulpiride reversed the D1R- and mGluR-dependent LTD to short-term potentiation. Therefore, the findings provide functional evidence that prenatal and neonatal exposure to low-dose BPA causes deficits in development of LTP and LTD at DL-striatum via altering the function of dopaminergic receptors.


PMID: 19162132 [PubMed - as supplied by publisher]










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